ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells

Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4(+) T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS(+) ce...

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Autores principales: Faget, Julien, Sisirak, Vanja, Blay, Jean-Yves, Caux, Christophe, Bendriss-Vermare, Nathalie, Ménétrier-Caux, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661154/
https://www.ncbi.nlm.nih.gov/pubmed/23802069
http://dx.doi.org/10.4161/onci.23185
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author Faget, Julien
Sisirak, Vanja
Blay, Jean-Yves
Caux, Christophe
Bendriss-Vermare, Nathalie
Ménétrier-Caux, Christine
author_facet Faget, Julien
Sisirak, Vanja
Blay, Jean-Yves
Caux, Christophe
Bendriss-Vermare, Nathalie
Ménétrier-Caux, Christine
author_sort Faget, Julien
collection PubMed
description Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4(+) T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS(+) cell infiltration correlates with adverse patient prognosis, identifying ICOS as a new target for cancer immunotherapy.
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spelling pubmed-36611542013-06-25 ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells Faget, Julien Sisirak, Vanja Blay, Jean-Yves Caux, Christophe Bendriss-Vermare, Nathalie Ménétrier-Caux, Christine Oncoimmunology Author's View Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) that infiltrate primary breast tumors impair patient survival. The ICOS-mediated interaction between tumor-infiltrating CD4(+) T cells and pDCs leads to the amplification of Tregs and interleukin-10 secretion. Importantly, ICOS(+) cell infiltration correlates with adverse patient prognosis, identifying ICOS as a new target for cancer immunotherapy. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661154/ /pubmed/23802069 http://dx.doi.org/10.4161/onci.23185 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Faget, Julien
Sisirak, Vanja
Blay, Jean-Yves
Caux, Christophe
Bendriss-Vermare, Nathalie
Ménétrier-Caux, Christine
ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title_full ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title_fullStr ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title_full_unstemmed ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title_short ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4(+) T cells by plasmacytoid dendritic cells
title_sort icos is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive cd4(+) t cells by plasmacytoid dendritic cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661154/
https://www.ncbi.nlm.nih.gov/pubmed/23802069
http://dx.doi.org/10.4161/onci.23185
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