Targeting two co-operating cytokines efficiently shapes immune responses

For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cance...

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Detalles Bibliográficos
Autores principales: Hombach, Andreas A., Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661157/
https://www.ncbi.nlm.nih.gov/pubmed/23802072
http://dx.doi.org/10.4161/onci.23205
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author Hombach, Andreas A.
Abken, Hinrich
author_facet Hombach, Andreas A.
Abken, Hinrich
author_sort Hombach, Andreas A.
collection PubMed
description For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone.
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spelling pubmed-36611572013-06-25 Targeting two co-operating cytokines efficiently shapes immune responses Hombach, Andreas A. Abken, Hinrich Oncoimmunology Author's View For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cancer than the use of each cytokine alone. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661157/ /pubmed/23802072 http://dx.doi.org/10.4161/onci.23205 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Hombach, Andreas A.
Abken, Hinrich
Targeting two co-operating cytokines efficiently shapes immune responses
title Targeting two co-operating cytokines efficiently shapes immune responses
title_full Targeting two co-operating cytokines efficiently shapes immune responses
title_fullStr Targeting two co-operating cytokines efficiently shapes immune responses
title_full_unstemmed Targeting two co-operating cytokines efficiently shapes immune responses
title_short Targeting two co-operating cytokines efficiently shapes immune responses
title_sort targeting two co-operating cytokines efficiently shapes immune responses
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661157/
https://www.ncbi.nlm.nih.gov/pubmed/23802072
http://dx.doi.org/10.4161/onci.23205
work_keys_str_mv AT hombachandreasa targetingtwocooperatingcytokinesefficientlyshapesimmuneresponses
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