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Targeting two co-operating cytokines efficiently shapes immune responses

For simultaneously mobilizing the adaptive and innate immune system against cancer, we fused interleukin (IL)-2 and IL-12 to generate a dual cytokine moiety that is targeted to neoplastic lesions by an antibody-binding domain. This approach elicits a broader attack of the immune system against cance...

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Detalles Bibliográficos
Autores principales: Hombach, Andreas A., Abken, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661157/
https://www.ncbi.nlm.nih.gov/pubmed/23802072
http://dx.doi.org/10.4161/onci.23205