Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity

The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferenti...

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Detalles Bibliográficos
Autores principales: Kabelitz, Dieter, Kalyan, Shirin, Oberg, Hans-Heinrich, Wesch, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661159/
https://www.ncbi.nlm.nih.gov/pubmed/23802074
http://dx.doi.org/10.4161/onci.23304
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author Kabelitz, Dieter
Kalyan, Shirin
Oberg, Hans-Heinrich
Wesch, Daniela
author_facet Kabelitz, Dieter
Kalyan, Shirin
Oberg, Hans-Heinrich
Wesch, Daniela
author_sort Kabelitz, Dieter
collection PubMed
description The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of Vδ2 versus non-Vδ2 γδ T cells as tools for future immunotherapeutic interventions against cancer.
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spelling pubmed-36611592013-06-25 Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity Kabelitz, Dieter Kalyan, Shirin Oberg, Hans-Heinrich Wesch, Daniela Oncoimmunology Point of View The Vδ2 and non-Vδ2 (mainly Vδ1) subsets of human γδ T cells have distinct homing patterns and recognize different types of ligands, yet both exert potent antitumor effects. While the T-cell receptor of Vδ2 T cells primarily recognizes tumor cell-derived pyrophosphates, non-Vδ2 γδ T cells preferentially recognize stress-associated surface antigens. Here, we discuss the pros and cons of Vδ2 versus non-Vδ2 γδ T cells as tools for future immunotherapeutic interventions against cancer. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661159/ /pubmed/23802074 http://dx.doi.org/10.4161/onci.23304 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Kabelitz, Dieter
Kalyan, Shirin
Oberg, Hans-Heinrich
Wesch, Daniela
Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title_full Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title_fullStr Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title_full_unstemmed Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title_short Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity
title_sort human vδ2 versus non-vδ2 γδ t cells in antitumor immunity
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661159/
https://www.ncbi.nlm.nih.gov/pubmed/23802074
http://dx.doi.org/10.4161/onci.23304
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AT oberghansheinrich humanvd2versusnonvd2gdtcellsinantitumorimmunity
AT weschdaniela humanvd2versusnonvd2gdtcellsinantitumorimmunity

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