A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils

Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs an...

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Detalles Bibliográficos
Autores principales: Manuel, Edwin R., Diamond, Don J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661160/
https://www.ncbi.nlm.nih.gov/pubmed/23802075
http://dx.doi.org/10.4161/onci.23322
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author Manuel, Edwin R.
Diamond, Don J.
author_facet Manuel, Edwin R.
Diamond, Don J.
author_sort Manuel, Edwin R.
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description Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer effects.
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spelling pubmed-36611602013-06-25 A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils Manuel, Edwin R. Diamond, Don J. Oncoimmunology Author's View Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer effects. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661160/ /pubmed/23802075 http://dx.doi.org/10.4161/onci.23322 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Manuel, Edwin R.
Diamond, Don J.
A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title_full A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title_fullStr A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title_full_unstemmed A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title_short A road less traveled paved by IDO silencing: Harnessing the antitumor activity of neutrophils
title_sort road less traveled paved by ido silencing: harnessing the antitumor activity of neutrophils
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661160/
https://www.ncbi.nlm.nih.gov/pubmed/23802075
http://dx.doi.org/10.4161/onci.23322
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