Non-classical MHC Class I molecules regulating natural killer cell function

Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the no...

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Detalles Bibliográficos
Autores principales: Smyth, Mark J., Sullivan, Lucy C., Brooks, Andrew G., Andrews, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661161/
https://www.ncbi.nlm.nih.gov/pubmed/23802076
http://dx.doi.org/10.4161/onci.23336
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author Smyth, Mark J.
Sullivan, Lucy C.
Brooks, Andrew G.
Andrews, Daniel M.
author_facet Smyth, Mark J.
Sullivan, Lucy C.
Brooks, Andrew G.
Andrews, Daniel M.
author_sort Smyth, Mark J.
collection PubMed
description Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.
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spelling pubmed-36611612013-06-25 Non-classical MHC Class I molecules regulating natural killer cell function Smyth, Mark J. Sullivan, Lucy C. Brooks, Andrew G. Andrews, Daniel M. Oncoimmunology Author's View Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661161/ /pubmed/23802076 http://dx.doi.org/10.4161/onci.23336 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Smyth, Mark J.
Sullivan, Lucy C.
Brooks, Andrew G.
Andrews, Daniel M.
Non-classical MHC Class I molecules regulating natural killer cell function
title Non-classical MHC Class I molecules regulating natural killer cell function
title_full Non-classical MHC Class I molecules regulating natural killer cell function
title_fullStr Non-classical MHC Class I molecules regulating natural killer cell function
title_full_unstemmed Non-classical MHC Class I molecules regulating natural killer cell function
title_short Non-classical MHC Class I molecules regulating natural killer cell function
title_sort non-classical mhc class i molecules regulating natural killer cell function
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661161/
https://www.ncbi.nlm.nih.gov/pubmed/23802076
http://dx.doi.org/10.4161/onci.23336
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