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MIF: metastasis/MDSC-inducing factor?
Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor....
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661162/ https://www.ncbi.nlm.nih.gov/pubmed/23802077 http://dx.doi.org/10.4161/onci.23337 |
| _version_ | 1782270638661042176 |
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| author | Simpson, Kendra D. Cross, Janet V. |
| author_facet | Simpson, Kendra D. Cross, Janet V. |
| author_sort | Simpson, Kendra D. |
| collection | PubMed |
| description | Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment. |
| format | Online Article Text |
| id | pubmed-3661162 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Landes Bioscience |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-36611622013-06-25 MIF: metastasis/MDSC-inducing factor? Simpson, Kendra D. Cross, Janet V. Oncoimmunology Author's View Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661162/ /pubmed/23802077 http://dx.doi.org/10.4161/onci.23337 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Author's View Simpson, Kendra D. Cross, Janet V. MIF: metastasis/MDSC-inducing factor? |
| title | MIF: metastasis/MDSC-inducing factor? |
| title_full | MIF: metastasis/MDSC-inducing factor? |
| title_fullStr | MIF: metastasis/MDSC-inducing factor? |
| title_full_unstemmed | MIF: metastasis/MDSC-inducing factor? |
| title_short | MIF: metastasis/MDSC-inducing factor? |
| title_sort | mif: metastasis/mdsc-inducing factor? |
| topic | Author's View |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661162/ https://www.ncbi.nlm.nih.gov/pubmed/23802077 http://dx.doi.org/10.4161/onci.23337 |
| work_keys_str_mv | AT simpsonkendrad mifmetastasismdscinducingfactor AT crossjanetv mifmetastasismdscinducingfactor |