Universal tumor-reactive helper peptides from telomerase as new tools for anticancer vaccination

Accumulating evidence demonstrates the importance of CD4(+) T cells in antitumor immune responses. Identifying promiscuous MHC class II-binding peptides derived from relevant tumor-associated antigens that specifically target CD4(+) helper T cells in vivo represent a powerful approach to fully explo...

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Detalles Bibliográficos
Autores principales: Dosset, Magalie, Vauchy, Charline, Beziaud, Laurent, Adotevi, Olivier, Godet, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661170/
https://www.ncbi.nlm.nih.gov/pubmed/23802085
http://dx.doi.org/10.4161/onci.23430
Descripción
Sumario:Accumulating evidence demonstrates the importance of CD4(+) T cells in antitumor immune responses. Identifying promiscuous MHC class II-binding peptides derived from relevant tumor-associated antigens that specifically target CD4(+) helper T cells in vivo represent a powerful approach to fully exploit these cells for anticancer immunotherapy.

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