Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy

Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the promi...

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Detalles Bibliográficos
Autores principales: Chang, Stephanie, Lin, Xue, Higashikubo, Ryuji, Toth, Kelsey, Gelman, Andrew E., Kreisel, Daniel, Krupnick, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Point of View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661173/
https://www.ncbi.nlm.nih.gov/pubmed/23802088
http://dx.doi.org/10.4161/onci.23563
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author Chang, Stephanie
Lin, Xue
Higashikubo, Ryuji
Toth, Kelsey
Gelman, Andrew E.
Kreisel, Daniel
Krupnick, Alexander S.
author_facet Chang, Stephanie
Lin, Xue
Higashikubo, Ryuji
Toth, Kelsey
Gelman, Andrew E.
Kreisel, Daniel
Krupnick, Alexander S.
author_sort Chang, Stephanie
collection PubMed
description Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.
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spelling pubmed-36611732013-06-25 Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy Chang, Stephanie Lin, Xue Higashikubo, Ryuji Toth, Kelsey Gelman, Andrew E. Kreisel, Daniel Krupnick, Alexander S. Oncoimmunology Point of View Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting. Landes Bioscience 2013-03-01 2013-03-01 /pmc/articles/PMC3661173/ /pubmed/23802088 http://dx.doi.org/10.4161/onci.23563 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Point of View
Chang, Stephanie
Lin, Xue
Higashikubo, Ryuji
Toth, Kelsey
Gelman, Andrew E.
Kreisel, Daniel
Krupnick, Alexander S.
Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title_full Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title_fullStr Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title_full_unstemmed Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title_short Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
title_sort unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy
topic Point of View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661173/
https://www.ncbi.nlm.nih.gov/pubmed/23802088
http://dx.doi.org/10.4161/onci.23563
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