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Prognostic value of CAPZA1 overexpression in gastric cancer

F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study. The association between CAPZA1 overexpression, detected by immunohistochemistry, and clinicopathological features including surviva...

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Autores principales: LEE, YOUNG-JOON, JEONG, SANG-HO, HONG, SOON-CHAN, CHO, BOK-IM, HA, WOO-SONG, PARK, SOON-TAE, CHOI, SANG-KYUNG, JUNG, EUN-JUNG, JU, YOUNG-TAE, JEONG, CHI-YOUNG, KIM, JAE WON, LEE, CHANG WON, YOO, JIYUN, KO, GYUNG HYUCK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661194/
https://www.ncbi.nlm.nih.gov/pubmed/23545944
http://dx.doi.org/10.3892/ijo.2013.1867
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author LEE, YOUNG-JOON
JEONG, SANG-HO
HONG, SOON-CHAN
CHO, BOK-IM
HA, WOO-SONG
PARK, SOON-TAE
CHOI, SANG-KYUNG
JUNG, EUN-JUNG
JU, YOUNG-TAE
JEONG, CHI-YOUNG
KIM, JAE WON
LEE, CHANG WON
YOO, JIYUN
KO, GYUNG HYUCK
author_facet LEE, YOUNG-JOON
JEONG, SANG-HO
HONG, SOON-CHAN
CHO, BOK-IM
HA, WOO-SONG
PARK, SOON-TAE
CHOI, SANG-KYUNG
JUNG, EUN-JUNG
JU, YOUNG-TAE
JEONG, CHI-YOUNG
KIM, JAE WON
LEE, CHANG WON
YOO, JIYUN
KO, GYUNG HYUCK
author_sort LEE, YOUNG-JOON
collection PubMed
description F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study. The association between CAPZA1 overexpression, detected by immunohistochemistry, and clinicopathological features including survival were evaluated. In vitro gain-of-function and loss-of-function approaches were utilized to assess the function of CPAZA1 in malignancy. Univariate analysis revealed that poorly differentiated disease, according to the World Health Organization (WHO) classification, advanced T stage, positive lymph nodes, high TNM stage, D2 lymph node dissection, adjuvant chemotherapy and CAPZA1 underexpression were significantly associated with cancer-related death (p<0.05); however, only high TNM stage remained significantly associated by multivariate analysis (p<0.01). CAPZA1 overexpression was associated with well differentiated histology, smaller tumor size, lower T stage, absence of lymph node metastasis, lower TNM stage, lower recurrence rate and longer survival time, compared to CAPZA1 underexpression. In vitro, forced expression of CAPZA1 caused a significant decrease in gastric cancer cell migration and invasion, whereas CAPZA1 depletion had the opposite effect. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.
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spelling pubmed-36611942013-05-22 Prognostic value of CAPZA1 overexpression in gastric cancer LEE, YOUNG-JOON JEONG, SANG-HO HONG, SOON-CHAN CHO, BOK-IM HA, WOO-SONG PARK, SOON-TAE CHOI, SANG-KYUNG JUNG, EUN-JUNG JU, YOUNG-TAE JEONG, CHI-YOUNG KIM, JAE WON LEE, CHANG WON YOO, JIYUN KO, GYUNG HYUCK Int J Oncol Articles F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study. The association between CAPZA1 overexpression, detected by immunohistochemistry, and clinicopathological features including survival were evaluated. In vitro gain-of-function and loss-of-function approaches were utilized to assess the function of CPAZA1 in malignancy. Univariate analysis revealed that poorly differentiated disease, according to the World Health Organization (WHO) classification, advanced T stage, positive lymph nodes, high TNM stage, D2 lymph node dissection, adjuvant chemotherapy and CAPZA1 underexpression were significantly associated with cancer-related death (p<0.05); however, only high TNM stage remained significantly associated by multivariate analysis (p<0.01). CAPZA1 overexpression was associated with well differentiated histology, smaller tumor size, lower T stage, absence of lymph node metastasis, lower TNM stage, lower recurrence rate and longer survival time, compared to CAPZA1 underexpression. In vitro, forced expression of CAPZA1 caused a significant decrease in gastric cancer cell migration and invasion, whereas CAPZA1 depletion had the opposite effect. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. D.A. Spandidos 2013-03-27 /pmc/articles/PMC3661194/ /pubmed/23545944 http://dx.doi.org/10.3892/ijo.2013.1867 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LEE, YOUNG-JOON
JEONG, SANG-HO
HONG, SOON-CHAN
CHO, BOK-IM
HA, WOO-SONG
PARK, SOON-TAE
CHOI, SANG-KYUNG
JUNG, EUN-JUNG
JU, YOUNG-TAE
JEONG, CHI-YOUNG
KIM, JAE WON
LEE, CHANG WON
YOO, JIYUN
KO, GYUNG HYUCK
Prognostic value of CAPZA1 overexpression in gastric cancer
title Prognostic value of CAPZA1 overexpression in gastric cancer
title_full Prognostic value of CAPZA1 overexpression in gastric cancer
title_fullStr Prognostic value of CAPZA1 overexpression in gastric cancer
title_full_unstemmed Prognostic value of CAPZA1 overexpression in gastric cancer
title_short Prognostic value of CAPZA1 overexpression in gastric cancer
title_sort prognostic value of capza1 overexpression in gastric cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661194/
https://www.ncbi.nlm.nih.gov/pubmed/23545944
http://dx.doi.org/10.3892/ijo.2013.1867
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