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Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD)
AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels. SUBJECTS AND METHODS: Serum from 22 children with ADHD and 20 healthy control children without ADHD and 19 autistic children without ADHD were tested...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Libertas Academica
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661234/ https://www.ncbi.nlm.nih.gov/pubmed/23861627 |
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author | Russo, A.J. |
author_facet | Russo, A.J. |
author_sort | Russo, A.J. |
collection | PubMed |
description | AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels. SUBJECTS AND METHODS: Serum from 22 children with ADHD and 20 healthy control children without ADHD and 19 autistic children without ADHD were tested for Cu/Zn SOD using ELISAs and levels of serum Cu and Zn using inductively-coupled plasma-mass spectrometry. RESULTS: Serum Cu/Zn SOD levels of ADHD children were significantly lower than age and gender matched healthy non-ADHD controls (P < 0.001). Serum Cu/Zn SOD of ADHD children was significantly lower in individuals with high serum copper (P = 0.024). There was no significant correlation between Cu/Zn SOD levels and Zinc or Cu/Zn in ADHD individuals. DISCUSSION: These results suggest an association between Cu/Zn SOD serum levels and ADHD, particularly ADHD children with high serum copper. |
format | Online Article Text |
id | pubmed-3661234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-36612342013-07-16 Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) Russo, A.J. J Cent Nerv Syst Dis Original Research AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels. SUBJECTS AND METHODS: Serum from 22 children with ADHD and 20 healthy control children without ADHD and 19 autistic children without ADHD were tested for Cu/Zn SOD using ELISAs and levels of serum Cu and Zn using inductively-coupled plasma-mass spectrometry. RESULTS: Serum Cu/Zn SOD levels of ADHD children were significantly lower than age and gender matched healthy non-ADHD controls (P < 0.001). Serum Cu/Zn SOD of ADHD children was significantly lower in individuals with high serum copper (P = 0.024). There was no significant correlation between Cu/Zn SOD levels and Zinc or Cu/Zn in ADHD individuals. DISCUSSION: These results suggest an association between Cu/Zn SOD serum levels and ADHD, particularly ADHD children with high serum copper. Libertas Academica 2010-05-04 /pmc/articles/PMC3661234/ /pubmed/23861627 Text en © 2010 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
spellingShingle | Original Research Russo, A.J. Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title | Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title_full | Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title_fullStr | Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title_full_unstemmed | Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title_short | Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD) |
title_sort | decreased serum cu/zn sod associated with high copper in children with attention deficit hyperactivity disorder (adhd) |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661234/ https://www.ncbi.nlm.nih.gov/pubmed/23861627 |
work_keys_str_mv | AT russoaj decreasedserumcuznsodassociatedwithhighcopperinchildrenwithattentiondeficithyperactivitydisorderadhd |