Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()

Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will pr...

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Detalles Bibliográficos
Autor principal: Shiva, Sruti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661298/
https://www.ncbi.nlm.nih.gov/pubmed/23710434
http://dx.doi.org/10.1016/j.redox.2012.11.005
Descripción
Sumario:Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion—an emerging subcellular target for its biological actions in tissues.

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