Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()

Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will pr...

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Detalles Bibliográficos
Autor principal: Shiva, Sruti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Graphical Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661298/
https://www.ncbi.nlm.nih.gov/pubmed/23710434
http://dx.doi.org/10.1016/j.redox.2012.11.005
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author Shiva, Sruti
author_facet Shiva, Sruti
author_sort Shiva, Sruti
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description Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion—an emerging subcellular target for its biological actions in tissues.
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spelling pubmed-36612982013-09-10 Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function() Shiva, Sruti Redox Biol Graphical Review Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion—an emerging subcellular target for its biological actions in tissues. Elsevier 2013-01-17 /pmc/articles/PMC3661298/ /pubmed/23710434 http://dx.doi.org/10.1016/j.redox.2012.11.005 Text en © 2013 The Author http://creativecommons.org/licenses/BY-license/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Graphical Review
Shiva, Sruti
Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title_full Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title_fullStr Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title_full_unstemmed Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title_short Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function()
title_sort nitrite: a physiological store of nitric oxide and modulator of mitochondrial function()
topic Graphical Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661298/
https://www.ncbi.nlm.nih.gov/pubmed/23710434
http://dx.doi.org/10.1016/j.redox.2012.11.005
work_keys_str_mv AT shivasruti nitriteaphysiologicalstoreofnitricoxideandmodulatorofmitochondrialfunction

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