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Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?
BACKGROUND: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. METHODS: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to rece...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661339/ https://www.ncbi.nlm.nih.gov/pubmed/23680457 http://dx.doi.org/10.1186/1550-2783-10-26 |
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author | Lugaresi, Rebeca Leme, Marco de Salles Painelli, Vítor Murai, Igor Hisashi Roschel, Hamilton Sapienza, Marcelo Tatit Lancha Junior, Antonio Herbert Gualano, Bruno |
author_facet | Lugaresi, Rebeca Leme, Marco de Salles Painelli, Vítor Murai, Igor Hisashi Roschel, Hamilton Sapienza, Marcelo Tatit Lancha Junior, Antonio Herbert Gualano, Bruno |
author_sort | Lugaresi, Rebeca |
collection | PubMed |
description | BACKGROUND: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. METHODS: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., ≥ 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by (51)Cr-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments. RESULTS: No significant differences were observed for (51)Cr-EDTA clearance throughout the trial (Creatine: Pre 101.42 ± 13.11, Post 108.78 ± 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 ± 17.64, Post 106.68 ± 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged. CONCLUSIONS: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement. TRIAL REGISTRATION: ClinicalTrials.gov NCT01817673 |
format | Online Article Text |
id | pubmed-3661339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36613392013-05-23 Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? Lugaresi, Rebeca Leme, Marco de Salles Painelli, Vítor Murai, Igor Hisashi Roschel, Hamilton Sapienza, Marcelo Tatit Lancha Junior, Antonio Herbert Gualano, Bruno J Int Soc Sports Nutr Research Article BACKGROUND: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. METHODS: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., ≥ 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by (51)Cr-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments. RESULTS: No significant differences were observed for (51)Cr-EDTA clearance throughout the trial (Creatine: Pre 101.42 ± 13.11, Post 108.78 ± 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 ± 17.64, Post 106.68 ± 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged. CONCLUSIONS: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement. TRIAL REGISTRATION: ClinicalTrials.gov NCT01817673 BioMed Central 2013-05-16 /pmc/articles/PMC3661339/ /pubmed/23680457 http://dx.doi.org/10.1186/1550-2783-10-26 Text en Copyright © 2013 Lugaresi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lugaresi, Rebeca Leme, Marco de Salles Painelli, Vítor Murai, Igor Hisashi Roschel, Hamilton Sapienza, Marcelo Tatit Lancha Junior, Antonio Herbert Gualano, Bruno Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title | Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title_full | Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title_fullStr | Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title_full_unstemmed | Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title_short | Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
title_sort | does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661339/ https://www.ncbi.nlm.nih.gov/pubmed/23680457 http://dx.doi.org/10.1186/1550-2783-10-26 |
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