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Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance

BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor protein is a central negative regulator of the PI3K/AKT signaling cascade and suppresses cell survival as well as cell proliferation. PTEN is found to be either inactivated or mutated in various human mal...

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Detalles Bibliográficos
Autores principales:	Singh, Mohan, Chaudhry, Parvesh, Fabi, Francois, Asselin, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661380/ https://www.ncbi.nlm.nih.gov/pubmed/23663432 http://dx.doi.org/10.1186/1471-2407-13-233

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