miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines

Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the...

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Detalles Bibliográficos
Autores principales: Arora, Himanshu, Qureshi, Rehana, Park, Woong-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661463/
https://www.ncbi.nlm.nih.gov/pubmed/23717581
http://dx.doi.org/10.1371/journal.pone.0064273
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author Arora, Himanshu
Qureshi, Rehana
Park, Woong-Yang
author_facet Arora, Himanshu
Qureshi, Rehana
Park, Woong-Yang
author_sort Arora, Himanshu
collection PubMed
description Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF-κB bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGFβ-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes.
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spelling pubmed-36614632013-05-28 miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines Arora, Himanshu Qureshi, Rehana Park, Woong-Yang PLoS One Research Article Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF-κB bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGFβ-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes. Public Library of Science 2013-05-22 /pmc/articles/PMC3661463/ /pubmed/23717581 http://dx.doi.org/10.1371/journal.pone.0064273 Text en © 2013 Arora et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Arora, Himanshu
Qureshi, Rehana
Park, Woong-Yang
miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title_full miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title_fullStr miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title_full_unstemmed miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title_short miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines
title_sort mir-506 regulates epithelial mesenchymal transition in breast cancer cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661463/
https://www.ncbi.nlm.nih.gov/pubmed/23717581
http://dx.doi.org/10.1371/journal.pone.0064273
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AT parkwoongyang mir506regulatesepithelialmesenchymaltransitioninbreastcancercelllines

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