Cargando…

Changes in Airway Histone Deacetylase2 in Smokers and COPD with Inhaled Corticosteroids: A Randomized Controlled Trial

The expression of HDAC2 is reported as reduced in chronic obstructive pulmonary disease (COPD). We assessed HDAC2 expression within the airways of smokers and subjects with COPD and effects of inhaled corticosteroids (ICS), using immuno-histology to contrast with previous molecular methodology. Endo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sohal, Sukhwinder Singh, Reid, David, Soltani, Amir, Weston, Steven, Muller, Hans Konrad, Wood-Baker, Richard, Walters, Eugene Haydn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661479/ https://www.ncbi.nlm.nih.gov/pubmed/23717666 http://dx.doi.org/10.1371/journal.pone.0064833

Ejemplares similares

Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD
por: Soltani, Amir, et al.
Publicado: (2016)

A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial–mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2014)

Vessel-Associated Transforming Growth Factor-Beta1 (TGF-β1) Is Increased in the Bronchial Reticular Basement Membrane in COPD and Normal Smokers
por: Soltani, Amir, et al.
Publicado: (2012)

Distinctive characteristics of bronchial reticular basement membrane and vessel remodelling in chronic obstructive pulmonary disease (COPD) and in asthma: they are not the same disease
por: Soltani, Amir, et al.
Publicado: (2012)

Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study
por: Soltani, Amir, et al.
Publicado: (2010)

Epithelial mesenchymal transition (EMT) in small airways of COPD patients
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2013)

Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2017)

β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction
por: Mahmood, Malik Quasir, et al.
Publicado: (2017)

Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable
por: Soltani, Amir, et al.
Publicado: (2012)

Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2014)

Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)
por: Sohal, Sukhwinder Singh, et al.
Publicado: (2013)

Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial–mesenchymal transition
por: Eapen, Mathew Suji, et al.
Publicado: (2021)

Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
por: Sohal, Sukhwinder S, et al.
Publicado: (2011)

Assessment of airway inflammation using sputum, BAL, and endobronchial biopsies in current and ex-smokers with established COPD
por: Wen, Yudong, et al.
Publicado: (2010)

Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction
por: Mahmood, Malik Quasir, et al.
Publicado: (2015)

The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL)
por: Shukla, Shakti Dhar, et al.
Publicado: (2017)

Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease
por: Shukla, Shakti Dhar, et al.
Publicado: (2014)

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)
por: Eapen, Mathew Suji, et al.
Publicado: (2017)

Inhaled Corticosteroids and the Lung Microbiome in COPD
por: Keir, Holly R., et al.
Publicado: (2021)

WNT/β-catenin pathway: A novel therapeutic target for attenuating airway remodelling and EMT in COPD
por: Eapen, Mathew Suji, et al.
Publicado: (2020)

Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension
por: Bhattarai, Prem, et al.
Publicado: (2022)

Inhaled corticosteroids in COPD and the risk of serious pneumonia
por: Suissa, Samy, et al.
Publicado: (2013)

Inhaled corticosteroids in COPD: Personalising the therapeutic choice
por: Shaw, J A, et al.
Publicado: (2018)

How inhaled corticosteroids target inflammation in COPD
por: Lea, Simon, et al.
Publicado: (2023)

Rational use of inhaled corticosteroids for the treatment of COPD
por: Quint, Jennifer K., et al.
Publicado: (2023)

Clinical Application of Forced Oscillation Technique (FOT) in Early Detection of Airway Changes in Smokers
por: Bhattarai, Prem, et al.
Publicado: (2020)

Withdrawal of inhaled corticosteroids in COPD patients: rationale and algorithms
por: Avdeev, Sergey, et al.
Publicado: (2019)

Inhaled corticosteroids and angiotensin-converting enzyme-2 in COPD
por: Lipworth, Brian, et al.
Publicado: (2021)

Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma
por: Gafar, Fajri, et al.
Publicado: (2018)

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD
por: Footitt, Joseph, et al.
Publicado: (2016)

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
por: van den Berge, Maarten, et al.
Publicado: (2014)

Patterns of airway inflammation and MMP-12 expression in smokers and ex-smokers with COPD
por: Babusyte, Agne, et al.
Publicado: (2007)

Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?
por: Sohal, Sukhwinder Singh
Publicado: (2017)

Size of Inhaled Corticosteroid and Small Airway Inflammation in Asthma
por: Park, Choon-Sik
Publicado: (2017)

Transforming growth factor-β1 and SMAD signalling pathway in the small airways of smokers and patients with COPD: potential role in driving fibrotic type-2 epithelial mesenchymal transition
por: Brake, Samuel James, et al.
Publicado: (2023)

Inhaled corticosteroids can reduce osteoporosis in female patients with COPD
por: Liu, Shih-Feng, et al.
Publicado: (2016)

Quality of life and adherence to inhaled corticosteroids and tiotropium in COPD are related
por: Koehorst-ter Huurne, Kirsten, et al.
Publicado: (2016)

Appropriate use of inhaled corticosteroids in COPD: the candidates for safe withdrawal
por: Yawn, Barbara P, et al.
Publicado: (2016)

The dose of inhaled corticosteroids in patients with COPD: when less is better
por: Izquierdo, José Luis, et al.
Publicado: (2018)

COPD and Osteoporosis: Associated Factors in Patients Treated with Inhaled Corticosteroids
por: Ozcakir, Suheda, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s0hbd8k361sj25j328sh9c6j5q