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4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms

OBJECTIVE: To investigate whether 4-hydroxynonenal (4-HNE) regulates asymmetric dimethylarginine (ADMA) metabolism through pathway independent of direct adduct formation with ADMA metabolizing enzyme and the involvement of microRNA (miRNA) miR-21 in human umbilical venous endothelial cells (HUVECs)....

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Detalles Bibliográficos
Autores principales:	Chen, Lei, Zhou, Ji-Peng, Kuang, Da-Bin, Tang, Jie, Li, Yuan-Jian, Chen, Xiao-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661487/ https://www.ncbi.nlm.nih.gov/pubmed/23717555 http://dx.doi.org/10.1371/journal.pone.0064148

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