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Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur

A bulk of studies in rodents and humans suggest that sleep facilitates different phases of learning and memory process, while sleep deprivation (SD) impairs these processes. Here we tested the hypothesis that SD could alter spatial learning and memory processing in a non-human primate, the grey mous...

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Autores principales: Rahman, Anisur, Languille, Solène, Lamberty, Yves, Babiloni, Claudio, Perret, Martine, Bordet, Regis, Blin, Olivier J., Jacob, Tom, Auffret, Alexandra, Schenker, Esther, Richardson, Jill, Pifferi, Fabien, Aujard, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661499/
https://www.ncbi.nlm.nih.gov/pubmed/23717620
http://dx.doi.org/10.1371/journal.pone.0064493
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author Rahman, Anisur
Languille, Solène
Lamberty, Yves
Babiloni, Claudio
Perret, Martine
Bordet, Regis
Blin, Olivier J.
Jacob, Tom
Auffret, Alexandra
Schenker, Esther
Richardson, Jill
Pifferi, Fabien
Aujard, Fabienne
author_facet Rahman, Anisur
Languille, Solène
Lamberty, Yves
Babiloni, Claudio
Perret, Martine
Bordet, Regis
Blin, Olivier J.
Jacob, Tom
Auffret, Alexandra
Schenker, Esther
Richardson, Jill
Pifferi, Fabien
Aujard, Fabienne
author_sort Rahman, Anisur
collection PubMed
description A bulk of studies in rodents and humans suggest that sleep facilitates different phases of learning and memory process, while sleep deprivation (SD) impairs these processes. Here we tested the hypothesis that SD could alter spatial learning and memory processing in a non-human primate, the grey mouse lemur (Microcebus murinus), which is an interesting model of aging and Alzheimer's disease (AD). Two sets of experiments were performed. In a first set of experiments, we investigated the effects of SD on spatial learning and memory retrieval after one day of training in a circular platform task. Eleven male mouse lemurs aged between 2 to 3 years were tested in three different conditions: without SD as a baseline reference, 8 h of SD before the training and 8 h of SD before the testing. The SD was confirmed by electroencephalographic recordings. Results showed no effect of SD on learning when SD was applied before the training. When the SD was applied before the testing, it induced an increase of the amount of errors and of the latency prior to reach the target. In a second set of experiments, we tested the effect of 8 h of SD on spatial memory retrieval after 3 days of training. Twenty male mouse lemurs aged between 2 to 3 years were tested in this set of experiments. In this condition, the SD did not affect memory retrieval. This is the first study that documents the disruptive effects of the SD on spatial memory retrieval in this primate which may serve as a new validated challenge to investigate the effects of new compounds along physiological and pathological aging.
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spelling pubmed-36614992013-05-28 Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur Rahman, Anisur Languille, Solène Lamberty, Yves Babiloni, Claudio Perret, Martine Bordet, Regis Blin, Olivier J. Jacob, Tom Auffret, Alexandra Schenker, Esther Richardson, Jill Pifferi, Fabien Aujard, Fabienne PLoS One Research Article A bulk of studies in rodents and humans suggest that sleep facilitates different phases of learning and memory process, while sleep deprivation (SD) impairs these processes. Here we tested the hypothesis that SD could alter spatial learning and memory processing in a non-human primate, the grey mouse lemur (Microcebus murinus), which is an interesting model of aging and Alzheimer's disease (AD). Two sets of experiments were performed. In a first set of experiments, we investigated the effects of SD on spatial learning and memory retrieval after one day of training in a circular platform task. Eleven male mouse lemurs aged between 2 to 3 years were tested in three different conditions: without SD as a baseline reference, 8 h of SD before the training and 8 h of SD before the testing. The SD was confirmed by electroencephalographic recordings. Results showed no effect of SD on learning when SD was applied before the training. When the SD was applied before the testing, it induced an increase of the amount of errors and of the latency prior to reach the target. In a second set of experiments, we tested the effect of 8 h of SD on spatial memory retrieval after 3 days of training. Twenty male mouse lemurs aged between 2 to 3 years were tested in this set of experiments. In this condition, the SD did not affect memory retrieval. This is the first study that documents the disruptive effects of the SD on spatial memory retrieval in this primate which may serve as a new validated challenge to investigate the effects of new compounds along physiological and pathological aging. Public Library of Science 2013-05-22 /pmc/articles/PMC3661499/ /pubmed/23717620 http://dx.doi.org/10.1371/journal.pone.0064493 Text en © 2013 Rahman et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rahman, Anisur
Languille, Solène
Lamberty, Yves
Babiloni, Claudio
Perret, Martine
Bordet, Regis
Blin, Olivier J.
Jacob, Tom
Auffret, Alexandra
Schenker, Esther
Richardson, Jill
Pifferi, Fabien
Aujard, Fabienne
Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title_full Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title_fullStr Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title_full_unstemmed Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title_short Sleep Deprivation Impairs Spatial Retrieval but Not Spatial Learning in the Non-Human Primate Grey Mouse Lemur
title_sort sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661499/
https://www.ncbi.nlm.nih.gov/pubmed/23717620
http://dx.doi.org/10.1371/journal.pone.0064493
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