Cargando…
HGPGD: The Human Gene Population Genetic Difference Database
Demographic events such as migration, and evolutionary events like mutation and recombination, have contributed to the genetic variations that are found in the human genome. During the evolution and differentiation of human populations, different functional genes and pathways (a group of genes that...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661546/ https://www.ncbi.nlm.nih.gov/pubmed/23717556 http://dx.doi.org/10.1371/journal.pone.0064150 |
_version_ | 1782270697452601344 |
---|---|
author | Jiang, Yongshuai Zhang, Ruijie Lv, Hongchao Li, Jin Wang, Miao Chang, Yiman Lv, Wenhua Sheng, Xin Zhang, Jingjing Liu, Panpan Zheng, Jiajia Shi, Miao Liu, Guiyou |
author_facet | Jiang, Yongshuai Zhang, Ruijie Lv, Hongchao Li, Jin Wang, Miao Chang, Yiman Lv, Wenhua Sheng, Xin Zhang, Jingjing Liu, Panpan Zheng, Jiajia Shi, Miao Liu, Guiyou |
author_sort | Jiang, Yongshuai |
collection | PubMed |
description | Demographic events such as migration, and evolutionary events like mutation and recombination, have contributed to the genetic variations that are found in the human genome. During the evolution and differentiation of human populations, different functional genes and pathways (a group of genes that act together to perform specific biological tasks) would have displayed different degrees of genetic diversity or evolutionary conservatism. To query the genetic differences of functional genes or pathways in populations, we have developed the human gene population genetic difference (HGPGD) database. Currently, 11 common population genetic features, 18,158 single human genes, 220 KEGG (Kyoto Encyclopedia of Genes and Genomes) human pathways and 4,639 Gene Ontology (GO) categories (3,269 in biological process; 862 in molecular function; and 508 in cellular component) are available in the HGPGD database. The 11 population genetic features are related mainly to three aspects: allele frequency, linkage disequilibrium pattern, and transferability of tagSNPs. By entering a list of Gene IDs, KEGG pathway IDs or GO category IDs and selecting a population genetic feature, users can search the genetic differences between pairwise HapMap populations. We hope that, when the researchers carry out gene-based, KEGG pathway-based or GO category-based research, they can take full account of the genetic differences between populations. The HGPGD database (V1.0) is available at http://www.bioapp.org/hgpgd. |
format | Online Article Text |
id | pubmed-3661546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36615462013-05-28 HGPGD: The Human Gene Population Genetic Difference Database Jiang, Yongshuai Zhang, Ruijie Lv, Hongchao Li, Jin Wang, Miao Chang, Yiman Lv, Wenhua Sheng, Xin Zhang, Jingjing Liu, Panpan Zheng, Jiajia Shi, Miao Liu, Guiyou PLoS One Research Article Demographic events such as migration, and evolutionary events like mutation and recombination, have contributed to the genetic variations that are found in the human genome. During the evolution and differentiation of human populations, different functional genes and pathways (a group of genes that act together to perform specific biological tasks) would have displayed different degrees of genetic diversity or evolutionary conservatism. To query the genetic differences of functional genes or pathways in populations, we have developed the human gene population genetic difference (HGPGD) database. Currently, 11 common population genetic features, 18,158 single human genes, 220 KEGG (Kyoto Encyclopedia of Genes and Genomes) human pathways and 4,639 Gene Ontology (GO) categories (3,269 in biological process; 862 in molecular function; and 508 in cellular component) are available in the HGPGD database. The 11 population genetic features are related mainly to three aspects: allele frequency, linkage disequilibrium pattern, and transferability of tagSNPs. By entering a list of Gene IDs, KEGG pathway IDs or GO category IDs and selecting a population genetic feature, users can search the genetic differences between pairwise HapMap populations. We hope that, when the researchers carry out gene-based, KEGG pathway-based or GO category-based research, they can take full account of the genetic differences between populations. The HGPGD database (V1.0) is available at http://www.bioapp.org/hgpgd. Public Library of Science 2013-05-22 /pmc/articles/PMC3661546/ /pubmed/23717556 http://dx.doi.org/10.1371/journal.pone.0064150 Text en © 2013 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jiang, Yongshuai Zhang, Ruijie Lv, Hongchao Li, Jin Wang, Miao Chang, Yiman Lv, Wenhua Sheng, Xin Zhang, Jingjing Liu, Panpan Zheng, Jiajia Shi, Miao Liu, Guiyou HGPGD: The Human Gene Population Genetic Difference Database |
title | HGPGD: The Human Gene Population Genetic Difference Database |
title_full | HGPGD: The Human Gene Population Genetic Difference Database |
title_fullStr | HGPGD: The Human Gene Population Genetic Difference Database |
title_full_unstemmed | HGPGD: The Human Gene Population Genetic Difference Database |
title_short | HGPGD: The Human Gene Population Genetic Difference Database |
title_sort | hgpgd: the human gene population genetic difference database |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661546/ https://www.ncbi.nlm.nih.gov/pubmed/23717556 http://dx.doi.org/10.1371/journal.pone.0064150 |
work_keys_str_mv | AT jiangyongshuai hgpgdthehumangenepopulationgeneticdifferencedatabase AT zhangruijie hgpgdthehumangenepopulationgeneticdifferencedatabase AT lvhongchao hgpgdthehumangenepopulationgeneticdifferencedatabase AT lijin hgpgdthehumangenepopulationgeneticdifferencedatabase AT wangmiao hgpgdthehumangenepopulationgeneticdifferencedatabase AT changyiman hgpgdthehumangenepopulationgeneticdifferencedatabase AT lvwenhua hgpgdthehumangenepopulationgeneticdifferencedatabase AT shengxin hgpgdthehumangenepopulationgeneticdifferencedatabase AT zhangjingjing hgpgdthehumangenepopulationgeneticdifferencedatabase AT liupanpan hgpgdthehumangenepopulationgeneticdifferencedatabase AT zhengjiajia hgpgdthehumangenepopulationgeneticdifferencedatabase AT shimiao hgpgdthehumangenepopulationgeneticdifferencedatabase AT liuguiyou hgpgdthehumangenepopulationgeneticdifferencedatabase |