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Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preecla...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661579/ https://www.ncbi.nlm.nih.gov/pubmed/23717445 http://dx.doi.org/10.1371/journal.pone.0063546 |
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author | Kuc, Sylwia Koster, Maria P. H. Franx, Arie Schielen, Peter C. J. I. Visser, Gerard H. A. |
author_facet | Kuc, Sylwia Koster, Maria P. H. Franx, Arie Schielen, Peter C. J. I. Visser, Gerard H. A. |
author_sort | Kuc, Sylwia |
collection | PubMed |
description | OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preeclampsia (EO-PE; delivery <34 weeks). The objective of the current study was to obtain the predictive value of these serum makers combined with maternal characteristics and first-trimester maternal mean arterial blood pressure (MAP) in a large series of patients, for both EO-PE and late onset PE (LO-PE; delivery ≥ 34 weeks). METHODS: This was a nested case-control study, using stored first-trimester maternal serum from women who developed EO-PE (n = 68) or LO-PE (n = 99), and 500 uncomplicated singleton pregnancies. Maternal characteristics, MAP, and pregnancy outcome were collected for each individual woman and used to calculate prior risks for PE in a multiple logistic regression model. Models containing prior PE risks, serum markers, and MAP were developed for the prediction of EO-PE and LO-PE. The model-predicted detection rates (DR) for fixed 10% false-positive rates were calculated for EO-PE and LO-PE with or without the presence of a small-for-gestational age infant (SGA, birth weight <10(th) centile). RESULTS: The best prediction model included maternal characteristics, MAP, PAPP-A, ADAM12, and PlGF, with DR of 72% for EO-PE and 49% for LO-PE. Prediction for PE with concomitant SGA was better than for PE alone (92% for EO-PE and 57% for LO-PE). CONCLUSION: First-trimester MAP, PAPP-A, ADAM12, and PlGF combined with maternal characteristics and MAP are promising markers in the risk assessment of PE, especially for EO-PE complicated by SGA. |
format | Online Article Text |
id | pubmed-3661579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36615792013-05-28 Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia Kuc, Sylwia Koster, Maria P. H. Franx, Arie Schielen, Peter C. J. I. Visser, Gerard H. A. PLoS One Research Article OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preeclampsia (EO-PE; delivery <34 weeks). The objective of the current study was to obtain the predictive value of these serum makers combined with maternal characteristics and first-trimester maternal mean arterial blood pressure (MAP) in a large series of patients, for both EO-PE and late onset PE (LO-PE; delivery ≥ 34 weeks). METHODS: This was a nested case-control study, using stored first-trimester maternal serum from women who developed EO-PE (n = 68) or LO-PE (n = 99), and 500 uncomplicated singleton pregnancies. Maternal characteristics, MAP, and pregnancy outcome were collected for each individual woman and used to calculate prior risks for PE in a multiple logistic regression model. Models containing prior PE risks, serum markers, and MAP were developed for the prediction of EO-PE and LO-PE. The model-predicted detection rates (DR) for fixed 10% false-positive rates were calculated for EO-PE and LO-PE with or without the presence of a small-for-gestational age infant (SGA, birth weight <10(th) centile). RESULTS: The best prediction model included maternal characteristics, MAP, PAPP-A, ADAM12, and PlGF, with DR of 72% for EO-PE and 49% for LO-PE. Prediction for PE with concomitant SGA was better than for PE alone (92% for EO-PE and 57% for LO-PE). CONCLUSION: First-trimester MAP, PAPP-A, ADAM12, and PlGF combined with maternal characteristics and MAP are promising markers in the risk assessment of PE, especially for EO-PE complicated by SGA. Public Library of Science 2013-05-22 /pmc/articles/PMC3661579/ /pubmed/23717445 http://dx.doi.org/10.1371/journal.pone.0063546 Text en © 2013 Kuc et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kuc, Sylwia Koster, Maria P. H. Franx, Arie Schielen, Peter C. J. I. Visser, Gerard H. A. Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title | Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title_full | Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title_fullStr | Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title_full_unstemmed | Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title_short | Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia |
title_sort | maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661579/ https://www.ncbi.nlm.nih.gov/pubmed/23717445 http://dx.doi.org/10.1371/journal.pone.0063546 |
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