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Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia

OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preecla...

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Autores principales: Kuc, Sylwia, Koster, Maria P. H., Franx, Arie, Schielen, Peter C. J. I., Visser, Gerard H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661579/
https://www.ncbi.nlm.nih.gov/pubmed/23717445
http://dx.doi.org/10.1371/journal.pone.0063546
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author Kuc, Sylwia
Koster, Maria P. H.
Franx, Arie
Schielen, Peter C. J. I.
Visser, Gerard H. A.
author_facet Kuc, Sylwia
Koster, Maria P. H.
Franx, Arie
Schielen, Peter C. J. I.
Visser, Gerard H. A.
author_sort Kuc, Sylwia
collection PubMed
description OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preeclampsia (EO-PE; delivery <34 weeks). The objective of the current study was to obtain the predictive value of these serum makers combined with maternal characteristics and first-trimester maternal mean arterial blood pressure (MAP) in a large series of patients, for both EO-PE and late onset PE (LO-PE; delivery ≥ 34 weeks). METHODS: This was a nested case-control study, using stored first-trimester maternal serum from women who developed EO-PE (n = 68) or LO-PE (n = 99), and 500 uncomplicated singleton pregnancies. Maternal characteristics, MAP, and pregnancy outcome were collected for each individual woman and used to calculate prior risks for PE in a multiple logistic regression model. Models containing prior PE risks, serum markers, and MAP were developed for the prediction of EO-PE and LO-PE. The model-predicted detection rates (DR) for fixed 10% false-positive rates were calculated for EO-PE and LO-PE with or without the presence of a small-for-gestational age infant (SGA, birth weight <10(th) centile). RESULTS: The best prediction model included maternal characteristics, MAP, PAPP-A, ADAM12, and PlGF, with DR of 72% for EO-PE and 49% for LO-PE. Prediction for PE with concomitant SGA was better than for PE alone (92% for EO-PE and 57% for LO-PE). CONCLUSION: First-trimester MAP, PAPP-A, ADAM12, and PlGF combined with maternal characteristics and MAP are promising markers in the risk assessment of PE, especially for EO-PE complicated by SGA.
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spelling pubmed-36615792013-05-28 Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia Kuc, Sylwia Koster, Maria P. H. Franx, Arie Schielen, Peter C. J. I. Visser, Gerard H. A. PLoS One Research Article OBJECTIVES: In a previous study, we have described the predictive value of first-trimester Pregnancy-Associated Plasma Protein-A (PAPP-A), free β-subunit of human Chorionic Gonadotropin (fβ-hCG), Placental Growth Factor (PlGF) and A Disintegrin And Metalloprotease 12 (ADAM12) for early onset preeclampsia (EO-PE; delivery <34 weeks). The objective of the current study was to obtain the predictive value of these serum makers combined with maternal characteristics and first-trimester maternal mean arterial blood pressure (MAP) in a large series of patients, for both EO-PE and late onset PE (LO-PE; delivery ≥ 34 weeks). METHODS: This was a nested case-control study, using stored first-trimester maternal serum from women who developed EO-PE (n = 68) or LO-PE (n = 99), and 500 uncomplicated singleton pregnancies. Maternal characteristics, MAP, and pregnancy outcome were collected for each individual woman and used to calculate prior risks for PE in a multiple logistic regression model. Models containing prior PE risks, serum markers, and MAP were developed for the prediction of EO-PE and LO-PE. The model-predicted detection rates (DR) for fixed 10% false-positive rates were calculated for EO-PE and LO-PE with or without the presence of a small-for-gestational age infant (SGA, birth weight <10(th) centile). RESULTS: The best prediction model included maternal characteristics, MAP, PAPP-A, ADAM12, and PlGF, with DR of 72% for EO-PE and 49% for LO-PE. Prediction for PE with concomitant SGA was better than for PE alone (92% for EO-PE and 57% for LO-PE). CONCLUSION: First-trimester MAP, PAPP-A, ADAM12, and PlGF combined with maternal characteristics and MAP are promising markers in the risk assessment of PE, especially for EO-PE complicated by SGA. Public Library of Science 2013-05-22 /pmc/articles/PMC3661579/ /pubmed/23717445 http://dx.doi.org/10.1371/journal.pone.0063546 Text en © 2013 Kuc et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kuc, Sylwia
Koster, Maria P. H.
Franx, Arie
Schielen, Peter C. J. I.
Visser, Gerard H. A.
Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title_full Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title_fullStr Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title_full_unstemmed Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title_short Maternal Characteristics, Mean Arterial Pressure and Serum Markers in Early Prediction of Preeclampsia
title_sort maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661579/
https://www.ncbi.nlm.nih.gov/pubmed/23717445
http://dx.doi.org/10.1371/journal.pone.0063546
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