Cargando…
High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda
BACKGROUND: Data on prevalence and incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Rwanda are scarce. METHODS: HBV status was assessed at baseline and Month 12, and anti-HCV antibodies at baseline, in a prospective cohort study of HIV-infected patients in Kigali, Rwanda...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661584/ https://www.ncbi.nlm.nih.gov/pubmed/23717409 http://dx.doi.org/10.1371/journal.pone.0063303 |
_version_ | 1782270706204016640 |
---|---|
author | Rusine, John Ondoa, Pascale Asiimwe-Kateera, Brenda Boer, Kimberly R. Uwimana, Jean Marie Mukabayire, Odette Zaaijer, Hans Mugabekazi, Julie Reiss, Peter van de Wijgert, Janneke H. |
author_facet | Rusine, John Ondoa, Pascale Asiimwe-Kateera, Brenda Boer, Kimberly R. Uwimana, Jean Marie Mukabayire, Odette Zaaijer, Hans Mugabekazi, Julie Reiss, Peter van de Wijgert, Janneke H. |
author_sort | Rusine, John |
collection | PubMed |
description | BACKGROUND: Data on prevalence and incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Rwanda are scarce. METHODS: HBV status was assessed at baseline and Month 12, and anti-HCV antibodies at baseline, in a prospective cohort study of HIV-infected patients in Kigali, Rwanda: 104 men and 114 women initiating antiretroviral therapy (ART) at baseline, and 200 women not yet eligible for ART. RESULTS: Baseline prevalence of active HBV infection (HBsAg positive), past or occult HBV infection (anti-HBc positive and HBsAg negative) and anti-HCV was 5.2%, 42.9%, and 5.7%, respectively. The active HBV incidence rate was 4.2/1,000 person years (PY). In a multivariable logistic regression model using baseline data, participants with WHO stage 3 or 4 HIV disease were 4.19 times (95% CI 1.21–14.47) more likely to have active HBV infection, and older patients were more likely to have evidence of past exposure to HBV (aRR 1.03 per year; 95%CI 1.01–1.06). Older age was also positively associated with having anti-HCV antibodies (aOR 1.09; 95%CI 1.04–1.14) while having a higher baseline HIV viral load was negatively associated with HCV (aOR 0.60; 95% CI 0.40–0.98). The median CD4 increase during the first 12 months of ART was lower for those with active HBV infection or anti-HCV at baseline. Almost all participants (88%) with active HBV infection who were on ART were receiving lamivudine monotherapy for HBV. CONCLUSION: HBV and HCV are common in HIV-infected patients in Rwanda. Regular HBsAg screening is needed to ensure that HIV-HBV co-infected patients receive an HBV-active ART regimen, and the prevalence of occult HBV infection should be determined. Improved access to HBV vaccination is recommended. Active HCV prevalence and incidence should be investigated further to determine whether HCV RNA PCR testing should be introduced in Rwanda. |
format | Online Article Text |
id | pubmed-3661584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36615842013-05-28 High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda Rusine, John Ondoa, Pascale Asiimwe-Kateera, Brenda Boer, Kimberly R. Uwimana, Jean Marie Mukabayire, Odette Zaaijer, Hans Mugabekazi, Julie Reiss, Peter van de Wijgert, Janneke H. PLoS One Research Article BACKGROUND: Data on prevalence and incidence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Rwanda are scarce. METHODS: HBV status was assessed at baseline and Month 12, and anti-HCV antibodies at baseline, in a prospective cohort study of HIV-infected patients in Kigali, Rwanda: 104 men and 114 women initiating antiretroviral therapy (ART) at baseline, and 200 women not yet eligible for ART. RESULTS: Baseline prevalence of active HBV infection (HBsAg positive), past or occult HBV infection (anti-HBc positive and HBsAg negative) and anti-HCV was 5.2%, 42.9%, and 5.7%, respectively. The active HBV incidence rate was 4.2/1,000 person years (PY). In a multivariable logistic regression model using baseline data, participants with WHO stage 3 or 4 HIV disease were 4.19 times (95% CI 1.21–14.47) more likely to have active HBV infection, and older patients were more likely to have evidence of past exposure to HBV (aRR 1.03 per year; 95%CI 1.01–1.06). Older age was also positively associated with having anti-HCV antibodies (aOR 1.09; 95%CI 1.04–1.14) while having a higher baseline HIV viral load was negatively associated with HCV (aOR 0.60; 95% CI 0.40–0.98). The median CD4 increase during the first 12 months of ART was lower for those with active HBV infection or anti-HCV at baseline. Almost all participants (88%) with active HBV infection who were on ART were receiving lamivudine monotherapy for HBV. CONCLUSION: HBV and HCV are common in HIV-infected patients in Rwanda. Regular HBsAg screening is needed to ensure that HIV-HBV co-infected patients receive an HBV-active ART regimen, and the prevalence of occult HBV infection should be determined. Improved access to HBV vaccination is recommended. Active HCV prevalence and incidence should be investigated further to determine whether HCV RNA PCR testing should be introduced in Rwanda. Public Library of Science 2013-05-22 /pmc/articles/PMC3661584/ /pubmed/23717409 http://dx.doi.org/10.1371/journal.pone.0063303 Text en © 2013 Rusine et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Rusine, John Ondoa, Pascale Asiimwe-Kateera, Brenda Boer, Kimberly R. Uwimana, Jean Marie Mukabayire, Odette Zaaijer, Hans Mugabekazi, Julie Reiss, Peter van de Wijgert, Janneke H. High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title | High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title_full | High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title_fullStr | High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title_full_unstemmed | High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title_short | High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda |
title_sort | high seroprevalence of hbv and hcv infection in hiv-infected adults in kigali, rwanda |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661584/ https://www.ncbi.nlm.nih.gov/pubmed/23717409 http://dx.doi.org/10.1371/journal.pone.0063303 |
work_keys_str_mv | AT rusinejohn highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT ondoapascale highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT asiimwekateerabrenda highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT boerkimberlyr highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT uwimanajeanmarie highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT mukabayireodette highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT zaaijerhans highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT mugabekazijulie highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT reisspeter highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda AT vandewijgertjannekeh highseroprevalenceofhbvandhcvinfectioninhivinfectedadultsinkigalirwanda |