Cargando…

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661619/ https://www.ncbi.nlm.nih.gov/pubmed/23349477 http://dx.doi.org/10.2337/db12-1039

Ejemplares similares

Sex-Specific Effect of Estrogen Sulfotransferase on Mouse Models of Type 2 Diabetes
por: Gao, Jie, et al.
Publicado: (2012)

Mice Lacking NKT Cells but with a Complete Complement of CD8(+) T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity
por: Mantell, Benjamin S., et al.
Publicado: (2011)

Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
por: Krishna, Kanthi B., et al.
Publicado: (2016)

Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4
por: Liu, Ailing, et al.
Publicado: (2018)

Physical Inactivity and Obesity Underlie the Insulin Resistance of Aging
por: Amati, Francesca, et al.
Publicado: (2009)

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities
por: Harmon, Daniel B., et al.
Publicado: (2019)

Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes
por: Li, Zhihui, et al.
Publicado: (2021)

Scutellaria baicalensis Alleviates Insulin Resistance in Diet-Induced Obese Mice by Modulating Inflammation
por: Na, Hyun-Young, et al.
Publicado: (2019)

Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice
por: Chang, Ting-Chen, et al.
Publicado: (2019)

SAT-189 Pheochromocytoma as a Rare Cause of Elevated Blood Pressure During Pregnancy
por: Alquadan, Hammam F, et al.
Publicado: (2020)

THU322 Lower HbA1c Is Associated With Lower In-Hospital Mortality In Patients With COVID-19
por: Tsikala Vafea, Maria, et al.
Publicado: (2023)

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c(+) Cells in Adipose Tissue and Liver
por: Stefanovic-Racic, Maja, et al.
Publicado: (2012)

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
por: Keung, Wendy, et al.
Publicado: (2013)

Dietary Eriodictyol Alleviates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obese Mice
por: Kwon, Eun-Young, et al.
Publicado: (2019)

Activation of PXR causes drug interactions with Paxlovid in transgenic mice
por: Lei, Saifei, et al.
Publicado: (2023)

Alleviation of Gut Inflammation by Cdx2/Pxr Pathway in a Mouse Model of Chemical Colitis
por: Dou, Wei, et al.
Publicado: (2012)

Biology of PXR: role in drug-hormone interactions
por: Wang, Jing, et al.
Publicado: (2014)

PXR as a mediator of herb–drug interaction
por: Hogle, Brett C., et al.
Publicado: (2017)

Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens
por: Wang, Jingyuan, et al.
Publicado: (2023)

Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
por: Ren, Lu, et al.
Publicado: (2022)

Frequency of genetic polymorphisms of PXR gene in the Brazilian population
por: Moreira, Ricardo P P, et al.
Publicado: (2011)

The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice
por: Gahir, Sarabjit S., et al.
Publicado: (2017)

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid
por: Brewer, Christopher Trent, et al.
Publicado: (2020)

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice
por: Sui, Yipeng, et al.
Publicado: (2021)

Human umbilical cord-derived mesenchymal stem cells alleviate insulin resistance in diet-induced obese mice via an interaction with splenocytes
por: Xue, Jing, et al.
Publicado: (2022)

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content
por: Coen, Paul M., et al.
Publicado: (2010)

Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice
por: Zhao, Qingyu, et al.
Publicado: (2021)

The role of pregnane X receptor (PXR) in substance metabolism
por: Lv, Ye, et al.
Publicado: (2022)

Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis
por: Gao, Li, et al.
Publicado: (2020)

The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity
por: Solas, Maite, et al.
Publicado: (2022)

A brief history of the discovery of PXR and CAR as xenobiotic receptors
por: Yan, Jiong, et al.
Publicado: (2016)

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice
por: Li, Wenqiang, et al.
Publicado: (2023)

ChIPing the cistrome of PXR in mouse liver
por: Cui, Julia Yue, et al.
Publicado: (2010)

PXR is a target of (-)-epicatechin in skeletal muscle
por: Ortiz-Flores, Miguel, et al.
Publicado: (2020)

Regulation of CAR and PXR Expression in Health and Disease
por: Daujat-Chavanieu, Martine, et al.
Publicado: (2020)

PXR: a center of transcriptional regulation in cancer
por: Xing, Yaqi, et al.
Publicado: (2020)

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
por: Karpale, Mikko, et al.
Publicado: (2022)

The Nuclear Receptor PXR in Chronic Liver Disease
por: Sayaf, Katia, et al.
Publicado: (2021)

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
por: Pavek, Petr
Publicado: (2016)

Fenofibrate alleviates insulin resistance by reducing tissue inflammation in obese ovariectomized mice
por: Lee, Jungu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lcq88muecconq3gjsr3ph7ianj