Enhanced NF-κB Activity Impairs Vascular Function Through PARP-1–, SP-1–, and COX-2–Dependent Mechanisms in Type 2 Diabetes

Type 2 diabetes (T2D) is associated with vascular dysfunction. We hypothesized that increased nuclear factor-κB (NF-κB) signaling contributes to vascular dysfunction in T2D. We treated type 2 diabetic (db(−)/db(−)) and control (db(−)/db(+)) mice with two NF-κB inhibitors (6 mg/kg dehydroxymethylepox...

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Detalles Bibliográficos
Autores principales: Kassan, Modar, Choi, Soo-Kyoung, Galán, Maria, Bishop, Alexander, Umezawa, Kazuo, Trebak, Mohamed, Belmadani, Souad, Matrougui, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661639/
https://www.ncbi.nlm.nih.gov/pubmed/23349490
http://dx.doi.org/10.2337/db12-1374

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