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Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance
Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and...
Autores principales: | Ahlqvist, Emma, Osmark, Peter, Kuulasmaa, Tiina, Pilgaard, Kasper, Omar, Bilal, Brøns, Charlotte, Kotova, Olga, Zetterqvist, Anna V., Stančáková, Alena, Jonsson, Anna, Hansson, Ola, Kuusisto, Johanna, Kieffer, Timothy J., Tuomi, Tiinamaija, Isomaa, Bo, Madsbad, Sten, Gomez, Maria F., Poulsen, Pernille, Laakso, Markku, Degerman, Eva, Pihlajamäki, Jussi, Wierup, Nils, Vaag, Allan, Groop, Leif, Lyssenko, Valeriya |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661641/ https://www.ncbi.nlm.nih.gov/pubmed/23349498 http://dx.doi.org/10.2337/db12-0976 |
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