Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet–Induced Obesity and Insulin Resistance in Mice

A nonsense mutation in cereblon (CRBN) causes a mild type of mental retardation in humans. An earlier study showed that CRBN negatively regulates the functional activity of AMP-activated protein kinase (AMPK) in vitro by binding directly to the α(1)-subunit of the AMPK complex. However, the in vivo...

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Detalles Bibliográficos
Autores principales: Lee, Kwang Min, Yang, Seung-Joo, Kim, Yong Deuk, Choi, Yoo Duk, Nam, Jong Hee, Choi, Cheol Soo, Choi, Hueng-Sik, Park, Chul-Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661653/
https://www.ncbi.nlm.nih.gov/pubmed/23349485
http://dx.doi.org/10.2337/db12-1030

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