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Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity

Islet autoimmunity precedes type 1 diabetes onset. We previously found that islet autoimmunity rarely starts before 6 months of age but reaches its highest incidence already at ∼1 year of age. We now examine whether homeostatic expansion and immune competence changes seen in a maturating immune syst...

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Detalles Bibliográficos
Autores principales:	Heninger, Anne-Kristin, Monti, Paolo, Wilhelm, Carmen, Schwaiger, Petra, Kuehn, Denise, Ziegler, Anette-G., Bonifacio, Ezio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661654/ https://www.ncbi.nlm.nih.gov/pubmed/23349478 http://dx.doi.org/10.2337/db12-0942

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