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Weight Change as a Predictor of Incidence and Remission of Insulin Resistance

OBJECTIVE: The objective of this study was to assess the longitudinal relationship of weight change on incidence and remission of insulin resistance (IR). METHODS: We performed a cohort study in apparently healthy Korean men, 30 to 59 years of age, who underwent a health checkup and were followed an...

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Autores principales: Chang, Yoosoo, Sung, Eunju, Yun, Kyung Eun, Jung, Hyun-Suk, Kim, Chan-Won, Kwon, Min-Jung, Cho, Sung-Il, Ryu, Seungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661661/
https://www.ncbi.nlm.nih.gov/pubmed/23717466
http://dx.doi.org/10.1371/journal.pone.0063690
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author Chang, Yoosoo
Sung, Eunju
Yun, Kyung Eun
Jung, Hyun-Suk
Kim, Chan-Won
Kwon, Min-Jung
Cho, Sung-Il
Ryu, Seungho
author_facet Chang, Yoosoo
Sung, Eunju
Yun, Kyung Eun
Jung, Hyun-Suk
Kim, Chan-Won
Kwon, Min-Jung
Cho, Sung-Il
Ryu, Seungho
author_sort Chang, Yoosoo
collection PubMed
description OBJECTIVE: The objective of this study was to assess the longitudinal relationship of weight change on incidence and remission of insulin resistance (IR). METHODS: We performed a cohort study in apparently healthy Korean men, 30 to 59 years of age, who underwent a health checkup and were followed annually or biennially between 2002 and 2009. The computer model of homeostasis model assessment, HOMA2-IR, was obtained at each visit, and IR was defined as HOMA2-IR ≥75th percentile. RESULTS: For IR development, 1,755 of the 6,612 IR-free participants at baseline developed IR (rate 5.1 per 100 person-years) during 34,294.8 person-years of follow-up. The hazard ratios (95% confidence intervals) for incident IR with weight changes of <−0.9 kg, 0.6–2.1 kg and ≥2.2 kg from visit 1 to visit 2 (average 1.8 years) compared to weight change of −0.9–0.5 kg (reference) were 0.78 (0.68–0.90), 1.19 (1.04–1.35) and 1.26 (1.11–1.44), respectively. This association persisted in normal-weight individuals or those without any metabolic syndrome traits and remained significant after introducing weight categories and confounders as time-dependent exposures (P-trend <0.001). For IR remission, 903 of 1,696 IR participants had no IR (remission rate 10.3 per 100 person-years) during 8,777.4 person-years of follow-up. IR remission decreased with increasing quartiles of weight change (P-trend <0.001) and this association persisted in normal-weight individuals. CONCLUSIONS: Weight gain was associated with increased IR development and decreased IR remission regardless of baseline BMI status. Preventing weight gain, even in healthy and normal-weight individuals, is an important strategy for reducing IR and its associated consequences.
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spelling pubmed-36616612013-05-28 Weight Change as a Predictor of Incidence and Remission of Insulin Resistance Chang, Yoosoo Sung, Eunju Yun, Kyung Eun Jung, Hyun-Suk Kim, Chan-Won Kwon, Min-Jung Cho, Sung-Il Ryu, Seungho PLoS One Research Article OBJECTIVE: The objective of this study was to assess the longitudinal relationship of weight change on incidence and remission of insulin resistance (IR). METHODS: We performed a cohort study in apparently healthy Korean men, 30 to 59 years of age, who underwent a health checkup and were followed annually or biennially between 2002 and 2009. The computer model of homeostasis model assessment, HOMA2-IR, was obtained at each visit, and IR was defined as HOMA2-IR ≥75th percentile. RESULTS: For IR development, 1,755 of the 6,612 IR-free participants at baseline developed IR (rate 5.1 per 100 person-years) during 34,294.8 person-years of follow-up. The hazard ratios (95% confidence intervals) for incident IR with weight changes of <−0.9 kg, 0.6–2.1 kg and ≥2.2 kg from visit 1 to visit 2 (average 1.8 years) compared to weight change of −0.9–0.5 kg (reference) were 0.78 (0.68–0.90), 1.19 (1.04–1.35) and 1.26 (1.11–1.44), respectively. This association persisted in normal-weight individuals or those without any metabolic syndrome traits and remained significant after introducing weight categories and confounders as time-dependent exposures (P-trend <0.001). For IR remission, 903 of 1,696 IR participants had no IR (remission rate 10.3 per 100 person-years) during 8,777.4 person-years of follow-up. IR remission decreased with increasing quartiles of weight change (P-trend <0.001) and this association persisted in normal-weight individuals. CONCLUSIONS: Weight gain was associated with increased IR development and decreased IR remission regardless of baseline BMI status. Preventing weight gain, even in healthy and normal-weight individuals, is an important strategy for reducing IR and its associated consequences. Public Library of Science 2013-05-22 /pmc/articles/PMC3661661/ /pubmed/23717466 http://dx.doi.org/10.1371/journal.pone.0063690 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chang, Yoosoo
Sung, Eunju
Yun, Kyung Eun
Jung, Hyun-Suk
Kim, Chan-Won
Kwon, Min-Jung
Cho, Sung-Il
Ryu, Seungho
Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title_full Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title_fullStr Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title_full_unstemmed Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title_short Weight Change as a Predictor of Incidence and Remission of Insulin Resistance
title_sort weight change as a predictor of incidence and remission of insulin resistance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661661/
https://www.ncbi.nlm.nih.gov/pubmed/23717466
http://dx.doi.org/10.1371/journal.pone.0063690
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