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Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index

OBJECTIVE: Transcutaneous oxygen tension (TcPO2) measures tissue perfusion and is important in the management of peripheral artery disease (PAD). Ankle brachial index (ABI) is used for the diagnosis of PAD and represents a predictor of major adverse cardiovascular events (MACE), even if in diabetes...

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Autores principales: Gazzaruso, Carmine, Coppola, Adriana, Falcone, Colomba, Luppi, Chiara, Montalcini, Tiziana, Baffero, Elisabetta, Gallotti, Pietro, Pujia, Arturo, Solerte, Sebastiano B., Pelissero, Gabriele, Giustina, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661826/
https://www.ncbi.nlm.nih.gov/pubmed/23404303
http://dx.doi.org/10.2337/dc12-1401
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author Gazzaruso, Carmine
Coppola, Adriana
Falcone, Colomba
Luppi, Chiara
Montalcini, Tiziana
Baffero, Elisabetta
Gallotti, Pietro
Pujia, Arturo
Solerte, Sebastiano B.
Pelissero, Gabriele
Giustina, Andrea
author_facet Gazzaruso, Carmine
Coppola, Adriana
Falcone, Colomba
Luppi, Chiara
Montalcini, Tiziana
Baffero, Elisabetta
Gallotti, Pietro
Pujia, Arturo
Solerte, Sebastiano B.
Pelissero, Gabriele
Giustina, Andrea
author_sort Gazzaruso, Carmine
collection PubMed
description OBJECTIVE: Transcutaneous oxygen tension (TcPO2) measures tissue perfusion and is important in the management of peripheral artery disease (PAD). Ankle brachial index (ABI) is used for the diagnosis of PAD and represents a predictor of major adverse cardiovascular events (MACE), even if in diabetes its diagnostic and predictive value seems to be reduced. No study has evaluated TcPO2 as a predictor of cardiovascular events. Aim of this longitudinal study was to assess whether TcPO2 is better than ABI at predicting MACE in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: Among 361 consecutive patients with apparently uncomplicated diabetes, 67 MACE occurred during a follow-up period of 45.8 ± 23.2 months. RESULTS: The percentage of both subjects with low ABI (≤0.9) and subjects with low TcPO2 (≤46 mmHg as measured by a receiver operating characteristic curve) was significantly (<0.001) greater among patients with than among those without MACEs (ABI 64.2 vs. 40.8; TcPO2 58.2 vs. 34%). The Kaplan-Meier method showed that both low ABI (Mantel log-rank test, 4.087; P = 0.043) and low TcPO2 (Mantel log-rank test, 33.748; P > 0.0001) were associated with a higher rate of MACEs. Cox regression analysis showed that low TcPO2 (hazard ratio 1.78 [95% CI 1.44–2.23]; P < 0.001) was a significant predictor of MACE, while ABI did not enter the model. CONCLUSIONS: This longitudinal study showed that TcPO2 may be a potential predictor of MACE among patients with uncomplicated type 2 diabetes and that its predictive value seems to be greater than that of ABI.
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spelling pubmed-36618262014-06-01 Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index Gazzaruso, Carmine Coppola, Adriana Falcone, Colomba Luppi, Chiara Montalcini, Tiziana Baffero, Elisabetta Gallotti, Pietro Pujia, Arturo Solerte, Sebastiano B. Pelissero, Gabriele Giustina, Andrea Diabetes Care Original Research OBJECTIVE: Transcutaneous oxygen tension (TcPO2) measures tissue perfusion and is important in the management of peripheral artery disease (PAD). Ankle brachial index (ABI) is used for the diagnosis of PAD and represents a predictor of major adverse cardiovascular events (MACE), even if in diabetes its diagnostic and predictive value seems to be reduced. No study has evaluated TcPO2 as a predictor of cardiovascular events. Aim of this longitudinal study was to assess whether TcPO2 is better than ABI at predicting MACE in type 2 diabetic patients. RESEARCH DESIGN AND METHODS: Among 361 consecutive patients with apparently uncomplicated diabetes, 67 MACE occurred during a follow-up period of 45.8 ± 23.2 months. RESULTS: The percentage of both subjects with low ABI (≤0.9) and subjects with low TcPO2 (≤46 mmHg as measured by a receiver operating characteristic curve) was significantly (<0.001) greater among patients with than among those without MACEs (ABI 64.2 vs. 40.8; TcPO2 58.2 vs. 34%). The Kaplan-Meier method showed that both low ABI (Mantel log-rank test, 4.087; P = 0.043) and low TcPO2 (Mantel log-rank test, 33.748; P > 0.0001) were associated with a higher rate of MACEs. Cox regression analysis showed that low TcPO2 (hazard ratio 1.78 [95% CI 1.44–2.23]; P < 0.001) was a significant predictor of MACE, while ABI did not enter the model. CONCLUSIONS: This longitudinal study showed that TcPO2 may be a potential predictor of MACE among patients with uncomplicated type 2 diabetes and that its predictive value seems to be greater than that of ABI. American Diabetes Association 2013-06 2013-05-15 /pmc/articles/PMC3661826/ /pubmed/23404303 http://dx.doi.org/10.2337/dc12-1401 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Gazzaruso, Carmine
Coppola, Adriana
Falcone, Colomba
Luppi, Chiara
Montalcini, Tiziana
Baffero, Elisabetta
Gallotti, Pietro
Pujia, Arturo
Solerte, Sebastiano B.
Pelissero, Gabriele
Giustina, Andrea
Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title_full Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title_fullStr Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title_full_unstemmed Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title_short Transcutaneous Oxygen Tension as a Potential Predictor of Cardiovascular Events in Type 2 Diabetes: Comparison with ankle-brachial index
title_sort transcutaneous oxygen tension as a potential predictor of cardiovascular events in type 2 diabetes: comparison with ankle-brachial index
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661826/
https://www.ncbi.nlm.nih.gov/pubmed/23404303
http://dx.doi.org/10.2337/dc12-1401
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