Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

Factors that sustain self-renewal of mouse embryonic stem cells (ESCs) are well described. In contrast, the machinery regulating exit from pluripotency is ill defined. In a large-scale small interfering RNA (siRNA) screen, we found that knockdown of the tumor suppressors Folliculin (Flcn) and Tsc2 p...

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Detalles Bibliográficos
Autores principales: Betschinger, Joerg, Nichols, Jennifer, Dietmann, Sabine, Corrin, Philip D., Paddison, Patrick J., Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661979/
https://www.ncbi.nlm.nih.gov/pubmed/23582324
http://dx.doi.org/10.1016/j.cell.2013.03.012

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