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An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting...

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Detalles Bibliográficos
Autores principales:	Li, Lihua, Wang, Yan, Chen, Jun, Cheng, Bi, Hu, Jiehua, Zhou, Yuehua, Gao, Xin, Gao, Liucun, Mei, Xifan, Sun, Meiyan, Zhang, Zhuomei, Song, Haifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662114/ https://www.ncbi.nlm.nih.gov/pubmed/23737831 http://dx.doi.org/10.1155/2013/423129

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