Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy

β-cell apoptosis is a significant contributor to β-cell dysfunction in diabetes and ER stress is among the factors that contributes to β-cell death. We previously identified that the Ca(2+)-independent phospholipase A(2)β (iPLA(2)β), which in islets is localized in β-cells, participates in ER stress...

Descripción completa

Detalles Bibliográficos
Autores principales: Lei, Xiaoyong, Bone, Robert N., Ali, Tomader, Wohltmann, Mary, Gai, Ying, Goodwin, Karen J., Bohrer, Alan E., Turk, John, Ramanadham, Sasanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662380/
https://www.ncbi.nlm.nih.gov/pubmed/23411472
http://dx.doi.org/10.4161/isl.23758

Ejemplares similares

Ejemplares similares