Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration

Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and...

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Autores principales: Corona, Erik, Chen, Rong, Sikora, Martin, Morgan, Alexander A., Patel, Chirag J., Ramesh, Aditya, Bustamante, Carlos D., Butte, Atul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662561/
https://www.ncbi.nlm.nih.gov/pubmed/23717210
http://dx.doi.org/10.1371/journal.pgen.1003447
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author Corona, Erik
Chen, Rong
Sikora, Martin
Morgan, Alexander A.
Patel, Chirag J.
Ramesh, Aditya
Bustamante, Carlos D.
Butte, Atul J.
author_facet Corona, Erik
Chen, Rong
Sikora, Martin
Morgan, Alexander A.
Patel, Chirag J.
Ramesh, Aditya
Bustamante, Carlos D.
Butte, Atul J.
author_sort Corona, Erik
collection PubMed
description Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. In addition, biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, and vitiligo have undergone genetic risk differentiation. This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. We anticipate that our findings will enable detailed analysis pertaining to the driving forces behind genetic risk differentiation.
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spelling pubmed-36625612013-05-28 Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration Corona, Erik Chen, Rong Sikora, Martin Morgan, Alexander A. Patel, Chirag J. Ramesh, Aditya Bustamante, Carlos D. Butte, Atul J. PLoS Genet Research Article Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. In addition, biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, and vitiligo have undergone genetic risk differentiation. This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. We anticipate that our findings will enable detailed analysis pertaining to the driving forces behind genetic risk differentiation. Public Library of Science 2013-05-23 /pmc/articles/PMC3662561/ /pubmed/23717210 http://dx.doi.org/10.1371/journal.pgen.1003447 Text en © 2013 Corona et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Corona, Erik
Chen, Rong
Sikora, Martin
Morgan, Alexander A.
Patel, Chirag J.
Ramesh, Aditya
Bustamante, Carlos D.
Butte, Atul J.
Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title_full Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title_fullStr Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title_full_unstemmed Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title_short Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
title_sort analysis of the genetic basis of disease in the context of worldwide human relationships and migration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662561/
https://www.ncbi.nlm.nih.gov/pubmed/23717210
http://dx.doi.org/10.1371/journal.pgen.1003447
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