A Self-Help Program for Memory CD8+ T Cells: Positive Feedback via CD40-CD40L Signaling as a Critical Determinant of Secondary Expansion

The ability of memory CD8+ T cells to rapidly proliferate and acquire cytolytic activity is critical for protective immunity against intracellular pathogens. The signals that control this recall response remain unclear. We show that CD40L production by memory CD8+ T cells themselves is an essential...

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Detalles Bibliográficos
Autores principales: Shugart, Jessica A., Bambina, Shelly, Alice, Alejandro F., Montler, Ryan, Bahjat, Keith S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662717/
https://www.ncbi.nlm.nih.gov/pubmed/23717671
http://dx.doi.org/10.1371/journal.pone.0064878

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