Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs

We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections...

Descripción completa

Detalles Bibliográficos
Autores principales: Sea, Vanessa Ramos Faria, Cruz, Ana Cecília Ribeiro, Gurgel, Ricardo Q., Nunes, Bruno Tardelli Diniz, Silva, Eliana Vieira Pinto, Dolabella, Silvio S., dos Santos, Roseli La Corte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662776/
https://www.ncbi.nlm.nih.gov/pubmed/23717529
http://dx.doi.org/10.1371/journal.pone.0064056
Descripción
Sumario:We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.

Ejemplares similares