Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs

We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections...

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Autores principales: Sea, Vanessa Ramos Faria, Cruz, Ana Cecília Ribeiro, Gurgel, Ricardo Q., Nunes, Bruno Tardelli Diniz, Silva, Eliana Vieira Pinto, Dolabella, Silvio S., dos Santos, Roseli La Corte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662776/
https://www.ncbi.nlm.nih.gov/pubmed/23717529
http://dx.doi.org/10.1371/journal.pone.0064056
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author Sea, Vanessa Ramos Faria
Cruz, Ana Cecília Ribeiro
Gurgel, Ricardo Q.
Nunes, Bruno Tardelli Diniz
Silva, Eliana Vieira Pinto
Dolabella, Silvio S.
dos Santos, Roseli La Corte
author_facet Sea, Vanessa Ramos Faria
Cruz, Ana Cecília Ribeiro
Gurgel, Ricardo Q.
Nunes, Bruno Tardelli Diniz
Silva, Eliana Vieira Pinto
Dolabella, Silvio S.
dos Santos, Roseli La Corte
author_sort Sea, Vanessa Ramos Faria
collection PubMed
description We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses.
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spelling pubmed-36627762013-05-28 Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs Sea, Vanessa Ramos Faria Cruz, Ana Cecília Ribeiro Gurgel, Ricardo Q. Nunes, Bruno Tardelli Diniz Silva, Eliana Vieira Pinto Dolabella, Silvio S. dos Santos, Roseli La Corte PLoS One Research Article We have identified fifty-eight samples that were positive for Dengue-4 among 119 samples with negative diagnoses for dengue via the Platelia™ dengue NS1 Ag in Aracaju, State of Sergipe, Brazil. We determined that the low sensitivity of the NS1 Ag test could be related to secondary dengue infections in the studied population. Therefore, we concluded that the sensitivity and specificity of the Platelia™ dengue NS1 Ag test as a screening method for monitoring circulating dengue serotypes must be reevaluated. In addition, regional endo-epidemic profiles should also be considered due to the prevalence of secondary responses. Public Library of Science 2013-05-23 /pmc/articles/PMC3662776/ /pubmed/23717529 http://dx.doi.org/10.1371/journal.pone.0064056 Text en © 2013 Sea et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sea, Vanessa Ramos Faria
Cruz, Ana Cecília Ribeiro
Gurgel, Ricardo Q.
Nunes, Bruno Tardelli Diniz
Silva, Eliana Vieira Pinto
Dolabella, Silvio S.
dos Santos, Roseli La Corte
Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title_full Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title_fullStr Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title_full_unstemmed Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title_short Underreporting of Dengue-4 in Brazil Due to Low Sensitivity of the NS1 Ag Test in Routine Control Programs
title_sort underreporting of dengue-4 in brazil due to low sensitivity of the ns1 ag test in routine control programs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662776/
https://www.ncbi.nlm.nih.gov/pubmed/23717529
http://dx.doi.org/10.1371/journal.pone.0064056
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