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Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension
Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carc...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Ophthalmological Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663067/ https://www.ncbi.nlm.nih.gov/pubmed/23730117 http://dx.doi.org/10.3341/kjo.2013.27.3.215 |
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author | Kiratli, Hayyam Tarlan, Berçin Söylemezoğlu, Figen |
author_facet | Kiratli, Hayyam Tarlan, Berçin Söylemezoğlu, Figen |
author_sort | Kiratli, Hayyam |
collection | PubMed |
description | Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient. |
format | Online Article Text |
id | pubmed-3663067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Ophthalmological Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-36630672013-06-01 Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension Kiratli, Hayyam Tarlan, Berçin Söylemezoğlu, Figen Korean J Ophthalmol Case Report Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient. The Korean Ophthalmological Society 2013-06 2013-04-02 /pmc/articles/PMC3663067/ /pubmed/23730117 http://dx.doi.org/10.3341/kjo.2013.27.3.215 Text en © 2013 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kiratli, Hayyam Tarlan, Berçin Söylemezoğlu, Figen Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title | Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title_full | Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title_fullStr | Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title_full_unstemmed | Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title_short | Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension |
title_sort | papillary thyroid carcinoma: bilateral choroidal metastases with extrascleral extension |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663067/ https://www.ncbi.nlm.nih.gov/pubmed/23730117 http://dx.doi.org/10.3341/kjo.2013.27.3.215 |
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