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Subcellular Clustering of the Phosphorylated WspR Response Regulator Protein Stimulates Its Diguanylate Cyclase Activity

WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of Pseudomonas aeruginosa on surfaces. Active WspR produces cyclic di-GMP (c-di-GMP), which in turn stimulates biofilm formation. In previous work, we found tha...

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Detalles Bibliográficos
Autores principales: Huangyutitham, Varisa, Güvener, Zehra Tüzün, Harwood, Caroline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663191/
https://www.ncbi.nlm.nih.gov/pubmed/23653447
http://dx.doi.org/10.1128/mBio.00242-13