Genetic visualization of notch signaling in mammalian neurogenesis

Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling m...

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Detalles Bibliográficos
Autores principales: Imayoshi, Itaru, Shimojo, Hiromi, Sakamoto, Masayuki, Ohtsuka, Toshiyuki, Kageyama, Ryoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663255/
https://www.ncbi.nlm.nih.gov/pubmed/22971775
http://dx.doi.org/10.1007/s00018-012-1151-x
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author Imayoshi, Itaru
Shimojo, Hiromi
Sakamoto, Masayuki
Ohtsuka, Toshiyuki
Kageyama, Ryoichiro
author_facet Imayoshi, Itaru
Shimojo, Hiromi
Sakamoto, Masayuki
Ohtsuka, Toshiyuki
Kageyama, Ryoichiro
author_sort Imayoshi, Itaru
collection PubMed
description Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.
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spelling pubmed-36632552013-05-24 Genetic visualization of notch signaling in mammalian neurogenesis Imayoshi, Itaru Shimojo, Hiromi Sakamoto, Masayuki Ohtsuka, Toshiyuki Kageyama, Ryoichiro Cell Mol Life Sci Review Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling. SP Birkhäuser Verlag Basel 2012-09-13 2013 /pmc/articles/PMC3663255/ /pubmed/22971775 http://dx.doi.org/10.1007/s00018-012-1151-x Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Imayoshi, Itaru
Shimojo, Hiromi
Sakamoto, Masayuki
Ohtsuka, Toshiyuki
Kageyama, Ryoichiro
Genetic visualization of notch signaling in mammalian neurogenesis
title Genetic visualization of notch signaling in mammalian neurogenesis
title_full Genetic visualization of notch signaling in mammalian neurogenesis
title_fullStr Genetic visualization of notch signaling in mammalian neurogenesis
title_full_unstemmed Genetic visualization of notch signaling in mammalian neurogenesis
title_short Genetic visualization of notch signaling in mammalian neurogenesis
title_sort genetic visualization of notch signaling in mammalian neurogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663255/
https://www.ncbi.nlm.nih.gov/pubmed/22971775
http://dx.doi.org/10.1007/s00018-012-1151-x
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