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The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies
SUMMARY: Reflectance confocal microscopy (RCM) is a new non-invasive imaging technique that enables visualizing cells and structures in living skin in real-time with resolution close to that of histological analysis. RCM has been successfully implemented in the assessment of benign and malignant les...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Derm101.com
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663336/ https://www.ncbi.nlm.nih.gov/pubmed/23785598 http://dx.doi.org/10.5826/dpc.0202a10 |
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author | Ulrich, Martina Lange-Asschenfeldt, Susanne Gonzalez, Salvador |
author_facet | Ulrich, Martina Lange-Asschenfeldt, Susanne Gonzalez, Salvador |
author_sort | Ulrich, Martina |
collection | PubMed |
description | SUMMARY: Reflectance confocal microscopy (RCM) is a new non-invasive imaging technique that enables visualizing cells and structures in living skin in real-time with resolution close to that of histological analysis. RCM has been successfully implemented in the assessment of benign and malignant lesions. Most importantly, it also enables monitoring dynamic changes in the skin over time and in response to different therapies, e.g., imiquimod, photodynamic therapy, and others. Given the often traumatic nature of skin cancer that affects both the physiology and the psychology of the patients, it is crucial to have methods that enable monitoring the response to treatment but that minimize the distress and discomfort associated with such process. This article provides a very brief overview of the fundamentals of RCM and then focuses on its recent employment as a monitoring tool in skin cancer and other pathologies that may require frequent follow-up. |
format | Online Article Text |
id | pubmed-3663336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Derm101.com |
record_format | MEDLINE/PubMed |
spelling | pubmed-36633362013-06-19 The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies Ulrich, Martina Lange-Asschenfeldt, Susanne Gonzalez, Salvador Dermatol Pract Concept Review SUMMARY: Reflectance confocal microscopy (RCM) is a new non-invasive imaging technique that enables visualizing cells and structures in living skin in real-time with resolution close to that of histological analysis. RCM has been successfully implemented in the assessment of benign and malignant lesions. Most importantly, it also enables monitoring dynamic changes in the skin over time and in response to different therapies, e.g., imiquimod, photodynamic therapy, and others. Given the often traumatic nature of skin cancer that affects both the physiology and the psychology of the patients, it is crucial to have methods that enable monitoring the response to treatment but that minimize the distress and discomfort associated with such process. This article provides a very brief overview of the fundamentals of RCM and then focuses on its recent employment as a monitoring tool in skin cancer and other pathologies that may require frequent follow-up. Derm101.com 2012-04-30 /pmc/articles/PMC3663336/ /pubmed/23785598 http://dx.doi.org/10.5826/dpc.0202a10 Text en Copyright: ©2012 Ulrich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Ulrich, Martina Lange-Asschenfeldt, Susanne Gonzalez, Salvador The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title | The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title_full | The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title_fullStr | The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title_full_unstemmed | The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title_short | The use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
title_sort | use of reflectance confocal microscopy for monitoring response to therapy of skin malignancies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663336/ https://www.ncbi.nlm.nih.gov/pubmed/23785598 http://dx.doi.org/10.5826/dpc.0202a10 |
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