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Extensive regression in pigmented skin lesions: a dangerous confounding feature

Spontaneous regression in melanomas is not an uncommon phenomenon, as it has been described in 10–35% of primary cutaneous lesions [1]. Regression does not appear to predict a more favorable course, since even fully regressed melanomas may progress into metastatic disease [2]. Several dermoscopic fe...

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Autores principales: Lallas, Aimilios, Apalla, Zoe, Moscarella, Elvira, Zalaudek, Iris, Tzellos, Thrasivoulos, Lefaki, Ioanna, Cota, Carlo, Argenziano, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Derm101.com 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663342/
https://www.ncbi.nlm.nih.gov/pubmed/23785596
http://dx.doi.org/10.5826/dpc.0202a08
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author Lallas, Aimilios
Apalla, Zoe
Moscarella, Elvira
Zalaudek, Iris
Tzellos, Thrasivoulos
Lefaki, Ioanna
Cota, Carlo
Argenziano, Giuseppe
author_facet Lallas, Aimilios
Apalla, Zoe
Moscarella, Elvira
Zalaudek, Iris
Tzellos, Thrasivoulos
Lefaki, Ioanna
Cota, Carlo
Argenziano, Giuseppe
author_sort Lallas, Aimilios
collection PubMed
description Spontaneous regression in melanomas is not an uncommon phenomenon, as it has been described in 10–35% of primary cutaneous lesions [1]. Regression does not appear to predict a more favorable course, since even fully regressed melanomas may progress into metastatic disease [2]. Several dermoscopic features have been correlated with the regression process, including white scar-like depigmented areas and gray-blue, pepper-like granules, which correspond to dermal scarring, pigment incontinence and presence of melanophages [3,4]. Regression may occur not only in melanomas, but also in melanocytic nevi, which similarly may exhibit white areas and gray-blue granules or areas under dermoscopy [5]. Overall, white areas have been proposed to be associated with the fibrosis type of regression and gray-blue areas to the melanosis type of regression of melanocytic tumors [3]. Lichen planus like keratosis (LPLK) is considered to represent a regressed solar lentigo or seborrheic keratosis. Dermoscopy of LPLK at the late stage of the regression process reveals a diffuse gray-blue granular pattern, similar to that observed in regressed melanocytic lesions [6]. In this context, when evaluating skin lesions that exhibit high degree of regression, interpretation of dermoscopic findings may be problematic, especially when no other dermoscopic clues can be recognized.
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spelling pubmed-36633422013-06-19 Extensive regression in pigmented skin lesions: a dangerous confounding feature Lallas, Aimilios Apalla, Zoe Moscarella, Elvira Zalaudek, Iris Tzellos, Thrasivoulos Lefaki, Ioanna Cota, Carlo Argenziano, Giuseppe Dermatol Pract Concept Observation Spontaneous regression in melanomas is not an uncommon phenomenon, as it has been described in 10–35% of primary cutaneous lesions [1]. Regression does not appear to predict a more favorable course, since even fully regressed melanomas may progress into metastatic disease [2]. Several dermoscopic features have been correlated with the regression process, including white scar-like depigmented areas and gray-blue, pepper-like granules, which correspond to dermal scarring, pigment incontinence and presence of melanophages [3,4]. Regression may occur not only in melanomas, but also in melanocytic nevi, which similarly may exhibit white areas and gray-blue granules or areas under dermoscopy [5]. Overall, white areas have been proposed to be associated with the fibrosis type of regression and gray-blue areas to the melanosis type of regression of melanocytic tumors [3]. Lichen planus like keratosis (LPLK) is considered to represent a regressed solar lentigo or seborrheic keratosis. Dermoscopy of LPLK at the late stage of the regression process reveals a diffuse gray-blue granular pattern, similar to that observed in regressed melanocytic lesions [6]. In this context, when evaluating skin lesions that exhibit high degree of regression, interpretation of dermoscopic findings may be problematic, especially when no other dermoscopic clues can be recognized. Derm101.com 2012-04-30 /pmc/articles/PMC3663342/ /pubmed/23785596 http://dx.doi.org/10.5826/dpc.0202a08 Text en Copyright: ©2012 Lallas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Observation
Lallas, Aimilios
Apalla, Zoe
Moscarella, Elvira
Zalaudek, Iris
Tzellos, Thrasivoulos
Lefaki, Ioanna
Cota, Carlo
Argenziano, Giuseppe
Extensive regression in pigmented skin lesions: a dangerous confounding feature
title Extensive regression in pigmented skin lesions: a dangerous confounding feature
title_full Extensive regression in pigmented skin lesions: a dangerous confounding feature
title_fullStr Extensive regression in pigmented skin lesions: a dangerous confounding feature
title_full_unstemmed Extensive regression in pigmented skin lesions: a dangerous confounding feature
title_short Extensive regression in pigmented skin lesions: a dangerous confounding feature
title_sort extensive regression in pigmented skin lesions: a dangerous confounding feature
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663342/
https://www.ncbi.nlm.nih.gov/pubmed/23785596
http://dx.doi.org/10.5826/dpc.0202a08
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