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Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions

OBJECTIVES: To evaluate the frequency of misclassifications of equivocal pigmented lesions according to the first step of the dermatoscopic 2-step algorithm. PATIENTS AND METHODS: 707 consecutive cases from 553 patients of central Europe and Australia were included in the study. Dermatoscopic images...

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Autores principales: Tschandl, Philipp, Rosendahl, Cliff, Kittler, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Derm101.com 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663352/
https://www.ncbi.nlm.nih.gov/pubmed/23785610
http://dx.doi.org/10.5826/dpc.0203a08
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author Tschandl, Philipp
Rosendahl, Cliff
Kittler, Harald
author_facet Tschandl, Philipp
Rosendahl, Cliff
Kittler, Harald
author_sort Tschandl, Philipp
collection PubMed
description OBJECTIVES: To evaluate the frequency of misclassifications of equivocal pigmented lesions according to the first step of the dermatoscopic 2-step algorithm. PATIENTS AND METHODS: 707 consecutive cases from 553 patients of central Europe and Australia were included in the study. Dermatoscopic images were evaluated in a blinded fashion for the presence of features described in the 2-step algorithm to determine their melanocytic or non-melanocytic origin. Mucosal, genital and non-pigmented lesions were excluded. RESULTS: The sensitivity of the first step was 97.1% for patients from Australia and 96.8% for patients from central Europe. The specificity was 33.6% for Australian patients and 67.9% for European patients. The most common reasons for misclassification were the presence of a pigmented network in a non-melanocytic lesion (n=68, 25.2%) and the absence of dermatoscopic features of melanocytic and non-melanocytic lesions in 69 (25.6%) non-melanocytic lesions. CONCLUSION: The first step of the dermatoscopic 2-step algorithm, if applied consistently, has high sensitivity but low specificity. Many non-melanocytic lesions, especially solar lentigines and seborrheic keratoses, are wrongly classified as melanocytic. The worse performance of the first step algorithm in Australian patients is probably due to a higher rate of solar lentigines in patients with severely sun-damaged skin.
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spelling pubmed-36633522013-06-19 Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions Tschandl, Philipp Rosendahl, Cliff Kittler, Harald Dermatol Pract Concept Research OBJECTIVES: To evaluate the frequency of misclassifications of equivocal pigmented lesions according to the first step of the dermatoscopic 2-step algorithm. PATIENTS AND METHODS: 707 consecutive cases from 553 patients of central Europe and Australia were included in the study. Dermatoscopic images were evaluated in a blinded fashion for the presence of features described in the 2-step algorithm to determine their melanocytic or non-melanocytic origin. Mucosal, genital and non-pigmented lesions were excluded. RESULTS: The sensitivity of the first step was 97.1% for patients from Australia and 96.8% for patients from central Europe. The specificity was 33.6% for Australian patients and 67.9% for European patients. The most common reasons for misclassification were the presence of a pigmented network in a non-melanocytic lesion (n=68, 25.2%) and the absence of dermatoscopic features of melanocytic and non-melanocytic lesions in 69 (25.6%) non-melanocytic lesions. CONCLUSION: The first step of the dermatoscopic 2-step algorithm, if applied consistently, has high sensitivity but low specificity. Many non-melanocytic lesions, especially solar lentigines and seborrheic keratoses, are wrongly classified as melanocytic. The worse performance of the first step algorithm in Australian patients is probably due to a higher rate of solar lentigines in patients with severely sun-damaged skin. Derm101.com 2012-07-31 /pmc/articles/PMC3663352/ /pubmed/23785610 http://dx.doi.org/10.5826/dpc.0203a08 Text en Copyright: ©2012 Tschandl et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research
Tschandl, Philipp
Rosendahl, Cliff
Kittler, Harald
Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title_full Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title_fullStr Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title_full_unstemmed Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title_short Accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
title_sort accuracy of the first step of the dermatoscopic 2-step algorithm for pigmented skin lesions
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663352/
https://www.ncbi.nlm.nih.gov/pubmed/23785610
http://dx.doi.org/10.5826/dpc.0203a08
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