Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against T-cell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that agains...

Descripción completa

Detalles Bibliográficos
Autores principales: Wakuda, Yusuke, Kubota, Takaaki, Shima, Hiroshi, Okada, Tadashi, Mitsuhashi, Shinya, Aoki, Naohito, Kikuchi, Kunimi, Kobayashi, Jun’ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663405/
_version_ 1782270990096531456
author Wakuda, Yusuke
Kubota, Takaaki
Shima, Hiroshi
Okada, Tadashi
Mitsuhashi, Shinya
Aoki, Naohito
Kikuchi, Kunimi
Kobayashi, Jun’ichi
author_facet Wakuda, Yusuke
Kubota, Takaaki
Shima, Hiroshi
Okada, Tadashi
Mitsuhashi, Shinya
Aoki, Naohito
Kikuchi, Kunimi
Kobayashi, Jun’ichi
author_sort Wakuda, Yusuke
collection PubMed
description Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against T-cell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
format Online
Article
Text
id pubmed-3663405
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-36634052013-05-28 Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase Wakuda, Yusuke Kubota, Takaaki Shima, Hiroshi Okada, Tadashi Mitsuhashi, Shinya Aoki, Naohito Kikuchi, Kunimi Kobayashi, Jun’ichi Mar Drugs Short Communication Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against T-cell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B). Molecular Diversity Preservation International (MDPI) 2006-02-21 /pmc/articles/PMC3663405/ Text en © 2006 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Short Communication
Wakuda, Yusuke
Kubota, Takaaki
Shima, Hiroshi
Okada, Tadashi
Mitsuhashi, Shinya
Aoki, Naohito
Kikuchi, Kunimi
Kobayashi, Jun’ichi
Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_full Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_fullStr Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_full_unstemmed Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_short Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
title_sort manzamenones inhibit t-cell protein tyrosine phosphatase
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663405/
work_keys_str_mv AT wakudayusuke manzamenonesinhibittcellproteintyrosinephosphatase
AT kubotatakaaki manzamenonesinhibittcellproteintyrosinephosphatase
AT shimahiroshi manzamenonesinhibittcellproteintyrosinephosphatase
AT okadatadashi manzamenonesinhibittcellproteintyrosinephosphatase
AT mitsuhashishinya manzamenonesinhibittcellproteintyrosinephosphatase
AT aokinaohito manzamenonesinhibittcellproteintyrosinephosphatase
AT kikuchikunimi manzamenonesinhibittcellproteintyrosinephosphatase
AT kobayashijunichi manzamenonesinhibittcellproteintyrosinephosphatase

Ejemplares similares