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Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.
Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antib...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663406/ |
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author | de Oliveira, Jaine H. H. L. Seleghim, Mirna H. R. Timm, Christoph Grube, Achim Köck, Matthias Nascimento, Gislene G.F. Martins, Ana Claudia T. Silva, Elissa G. O. de Souza, Ana Olívia Minarini, Paulo R. R. Galetti, Fabio C. S. Silva, Célio L. Hajdu, Eduardo Berlinck, Roberto G. S. |
author_facet | de Oliveira, Jaine H. H. L. Seleghim, Mirna H. R. Timm, Christoph Grube, Achim Köck, Matthias Nascimento, Gislene G.F. Martins, Ana Claudia T. Silva, Elissa G. O. de Souza, Ana Olívia Minarini, Paulo R. R. Galetti, Fabio C. S. Silva, Célio L. Hajdu, Eduardo Berlinck, Roberto G. S. |
author_sort | de Oliveira, Jaine H. H. L. |
collection | PubMed |
description | Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines. |
format | Online Article Text |
id | pubmed-3663406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-36634062013-05-28 Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. de Oliveira, Jaine H. H. L. Seleghim, Mirna H. R. Timm, Christoph Grube, Achim Köck, Matthias Nascimento, Gislene G.F. Martins, Ana Claudia T. Silva, Elissa G. O. de Souza, Ana Olívia Minarini, Paulo R. R. Galetti, Fabio C. S. Silva, Célio L. Hajdu, Eduardo Berlinck, Roberto G. S. Mar Drugs Full Research Article Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and antibiotic-susceptible Escherichia coli and Candida albicans, as well as in antimycobacterial activity against Mycobacterium tuberculosis H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines. Molecular Diversity Preservation International (MDPI) 2005-01-20 /pmc/articles/PMC3663406/ Text en © 2006 by MDPI Reproduction is permitted for noncommercial purposes. |
spellingShingle | Full Research Article de Oliveira, Jaine H. H. L. Seleghim, Mirna H. R. Timm, Christoph Grube, Achim Köck, Matthias Nascimento, Gislene G.F. Martins, Ana Claudia T. Silva, Elissa G. O. de Souza, Ana Olívia Minarini, Paulo R. R. Galetti, Fabio C. S. Silva, Célio L. Hajdu, Eduardo Berlinck, Roberto G. S. Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title_full | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title_fullStr | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title_full_unstemmed | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title_short | Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp. |
title_sort | antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge pachychalina sp. |
topic | Full Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663406/ |
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