The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent wo...

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Detalles Bibliográficos
Autores principales: Geffeney, Shana L., Ruben, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663409/
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author Geffeney, Shana L.
Ruben, Peter C.
author_facet Geffeney, Shana L.
Ruben, Peter C.
author_sort Geffeney, Shana L.
collection PubMed
description Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
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spelling pubmed-36634092013-05-28 The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels Geffeney, Shana L. Ruben, Peter C. Mar Drugs Review Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV. Molecular Diversity Preservation International (MDPI) 2006-04-06 /pmc/articles/PMC3663409/ Text en © 2006 by MDPI Reproduction is permitted for noncommercial purposes.
spellingShingle Review
Geffeney, Shana L.
Ruben, Peter C.
The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title_full The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title_fullStr The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title_full_unstemmed The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title_short The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels
title_sort structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663409/
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