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Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases

BACKGROUND: The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible for the terminal illness. METHODS: We used immunohistochemistry based on a highl...

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Autores principales: Siraj, Ahsan, Desestret, Virginie, Antoine, Martine, Fromont, Gaëlle, Huerre, Michel, Sanson, Marc, Camparo, Philippe, Pichon, Christophe, Planeix, François, Gonin, Julie, Radu, Aurelian, Ghinea, Nicolae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663659/
https://www.ncbi.nlm.nih.gov/pubmed/23688201
http://dx.doi.org/10.1186/1471-2407-13-246
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author Siraj, Ahsan
Desestret, Virginie
Antoine, Martine
Fromont, Gaëlle
Huerre, Michel
Sanson, Marc
Camparo, Philippe
Pichon, Christophe
Planeix, François
Gonin, Julie
Radu, Aurelian
Ghinea, Nicolae
author_facet Siraj, Ahsan
Desestret, Virginie
Antoine, Martine
Fromont, Gaëlle
Huerre, Michel
Sanson, Marc
Camparo, Philippe
Pichon, Christophe
Planeix, François
Gonin, Julie
Radu, Aurelian
Ghinea, Nicolae
author_sort Siraj, Ahsan
collection PubMed
description BACKGROUND: The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible for the terminal illness. METHODS: We used immunohistochemistry based on a highly FSHR-specific monoclonal antibody to detect FSHR in cancer metastases from 6 major tumor types (lung, breast, prostate, colon, kidney, and leiomyosarcoma ) to 6 frequent locations (bone, liver, lymph node, brain, lung, and pleura) of 209 patients. RESULTS: In 166 patients examined (79%), FSHR was expressed by blood vessels associated with metastatic tissue. FSHR-positive vessels were present in the interior of the tumors and some few millimeters outside, in the normally appearing tissue. In the interior of the metastases, the density of the FSHR-positive vessels was constant up to 7 mm, the maximum depth available in the analyzed sections. No significant differences were noticed between the density of FSHR-positive vessels inside vs. outside tumors for metastases from lung, breast, colon, and kidney cancers. In contrast, for prostate cancer metastases, the density of FSHR-positive vessels was about 3-fold higher at the exterior of the tumor compared to the interior. Among brain metastases, the density of FSHR-positive vessels was highest in lung and kidney cancer, and lowest in prostate and colon cancer. In metastases of breast cancer to the lung pleura, the percentage of blood vessels expressing FSHR was positively correlated with the progesterone receptor level, but not with either HER-2 or estrogen receptors. In normal tissues corresponding to the host organs for the analyzed metastases, obtained from patients not known to have cancer, FSHR staining was absent, with the exception of approx. 1% of the vessels in non tumoral temporal lobe epilepsy samples. CONCLUSION: FSHR is expressed by the endothelium of blood vessels in the majority of metastatic tumors.
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spelling pubmed-36636592013-05-25 Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases Siraj, Ahsan Desestret, Virginie Antoine, Martine Fromont, Gaëlle Huerre, Michel Sanson, Marc Camparo, Philippe Pichon, Christophe Planeix, François Gonin, Julie Radu, Aurelian Ghinea, Nicolae BMC Cancer Research Article BACKGROUND: The Follicle Stimulating Hormone receptor (FSHR) is expressed by the vascular endothelium in a wide range of human tumors. It was not determined however if FSHR is present in metastases which are responsible for the terminal illness. METHODS: We used immunohistochemistry based on a highly FSHR-specific monoclonal antibody to detect FSHR in cancer metastases from 6 major tumor types (lung, breast, prostate, colon, kidney, and leiomyosarcoma ) to 6 frequent locations (bone, liver, lymph node, brain, lung, and pleura) of 209 patients. RESULTS: In 166 patients examined (79%), FSHR was expressed by blood vessels associated with metastatic tissue. FSHR-positive vessels were present in the interior of the tumors and some few millimeters outside, in the normally appearing tissue. In the interior of the metastases, the density of the FSHR-positive vessels was constant up to 7 mm, the maximum depth available in the analyzed sections. No significant differences were noticed between the density of FSHR-positive vessels inside vs. outside tumors for metastases from lung, breast, colon, and kidney cancers. In contrast, for prostate cancer metastases, the density of FSHR-positive vessels was about 3-fold higher at the exterior of the tumor compared to the interior. Among brain metastases, the density of FSHR-positive vessels was highest in lung and kidney cancer, and lowest in prostate and colon cancer. In metastases of breast cancer to the lung pleura, the percentage of blood vessels expressing FSHR was positively correlated with the progesterone receptor level, but not with either HER-2 or estrogen receptors. In normal tissues corresponding to the host organs for the analyzed metastases, obtained from patients not known to have cancer, FSHR staining was absent, with the exception of approx. 1% of the vessels in non tumoral temporal lobe epilepsy samples. CONCLUSION: FSHR is expressed by the endothelium of blood vessels in the majority of metastatic tumors. BioMed Central 2013-05-20 /pmc/articles/PMC3663659/ /pubmed/23688201 http://dx.doi.org/10.1186/1471-2407-13-246 Text en Copyright © 2013 Siraj et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Siraj, Ahsan
Desestret, Virginie
Antoine, Martine
Fromont, Gaëlle
Huerre, Michel
Sanson, Marc
Camparo, Philippe
Pichon, Christophe
Planeix, François
Gonin, Julie
Radu, Aurelian
Ghinea, Nicolae
Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title_full Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title_fullStr Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title_full_unstemmed Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title_short Expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
title_sort expression of follicle-stimulating hormone receptor by the vascular endothelium in tumor metastases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663659/
https://www.ncbi.nlm.nih.gov/pubmed/23688201
http://dx.doi.org/10.1186/1471-2407-13-246
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