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Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish

BACKGROUND: Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatases have been implicated in a number of tumorigenesis and metastasis processes a...

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Autores principales: Lin, Ming-Der, Lee, Hsun-Tzu, Wang, Szu-Chieh, Li, Han-Ru, Hsien, Hsin-Lun, Cheng, Kai-Wen, Chang, Yu-Di, Huang, Min-Lang, Yu, Jr-Kai, Chen, Yau-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663695/
https://www.ncbi.nlm.nih.gov/pubmed/23641863
http://dx.doi.org/10.1186/1471-213X-13-18
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author Lin, Ming-Der
Lee, Hsun-Tzu
Wang, Szu-Chieh
Li, Han-Ru
Hsien, Hsin-Lun
Cheng, Kai-Wen
Chang, Yu-Di
Huang, Min-Lang
Yu, Jr-Kai
Chen, Yau-Hung
author_facet Lin, Ming-Der
Lee, Hsun-Tzu
Wang, Szu-Chieh
Li, Han-Ru
Hsien, Hsin-Lun
Cheng, Kai-Wen
Chang, Yu-Di
Huang, Min-Lang
Yu, Jr-Kai
Chen, Yau-Hung
author_sort Lin, Ming-Der
collection PubMed
description BACKGROUND: Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatases have been implicated in a number of tumorigenesis and metastasis processes and are highly conserved. However, the understanding of PRL expression profiles during embryonic development is very limited. RESULTS: In this study, we demonstrated and characterized the comprehensive expression pattern of Drosophila PRL, amphioxus PRL, and zebrafish PRLs during embryonic development by either whole mount immunostaining or in situ hybridization. Our results indicate that Drosophila PRL is mainly enriched in developing mid-guts and central nervous system (CNS) in embryogenesis. In amphioxus, initially PRL gene is expressed ubiquitously during early embryogenesis, but its expression become restricted to the anterior neural tube in the cerebral vesicle. In zebrafish, PRL-1 and PRL-2 share similar expression patterns, most of which are neuronal lineages. In contrast, the expression of zebrafish PRL-3 is more specific and preferential in muscle. CONCLUSIONS: This study, for the first time, elucidated the embryonic expression pattern of Drosophila, amphioxus, and zebrafish PRL genes. The shared PRL expression pattern in the developing CNS among diverse animals suggests that PRL may play conserved roles in these animals for CNS development.
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spelling pubmed-36636952013-05-25 Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish Lin, Ming-Der Lee, Hsun-Tzu Wang, Szu-Chieh Li, Han-Ru Hsien, Hsin-Lun Cheng, Kai-Wen Chang, Yu-Di Huang, Min-Lang Yu, Jr-Kai Chen, Yau-Hung BMC Dev Biol Research Article BACKGROUND: Phosphatase of regenerating liver (PRL) family is classified as class IVa of protein tyrosine phosphatase (PTP4A) that removes phosphate groups from phosphorylated tyrosine residues on proteins. PRL phosphatases have been implicated in a number of tumorigenesis and metastasis processes and are highly conserved. However, the understanding of PRL expression profiles during embryonic development is very limited. RESULTS: In this study, we demonstrated and characterized the comprehensive expression pattern of Drosophila PRL, amphioxus PRL, and zebrafish PRLs during embryonic development by either whole mount immunostaining or in situ hybridization. Our results indicate that Drosophila PRL is mainly enriched in developing mid-guts and central nervous system (CNS) in embryogenesis. In amphioxus, initially PRL gene is expressed ubiquitously during early embryogenesis, but its expression become restricted to the anterior neural tube in the cerebral vesicle. In zebrafish, PRL-1 and PRL-2 share similar expression patterns, most of which are neuronal lineages. In contrast, the expression of zebrafish PRL-3 is more specific and preferential in muscle. CONCLUSIONS: This study, for the first time, elucidated the embryonic expression pattern of Drosophila, amphioxus, and zebrafish PRL genes. The shared PRL expression pattern in the developing CNS among diverse animals suggests that PRL may play conserved roles in these animals for CNS development. BioMed Central 2013-05-04 /pmc/articles/PMC3663695/ /pubmed/23641863 http://dx.doi.org/10.1186/1471-213X-13-18 Text en Copyright © 2013 Lin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Ming-Der
Lee, Hsun-Tzu
Wang, Szu-Chieh
Li, Han-Ru
Hsien, Hsin-Lun
Cheng, Kai-Wen
Chang, Yu-Di
Huang, Min-Lang
Yu, Jr-Kai
Chen, Yau-Hung
Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title_full Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title_fullStr Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title_full_unstemmed Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title_short Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish
title_sort expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among drosophila, amphioxus, and zebrafish
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663695/
https://www.ncbi.nlm.nih.gov/pubmed/23641863
http://dx.doi.org/10.1186/1471-213X-13-18
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