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The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-α production

BACKGROUND: CTLA-4 (Cytotoxic T lymphocyte antigen-4) is traditionally known as a negative regulator of T cell activation. The blocking of CTLA-4 using human monoclonal antibodies, such as Ipilimumab, is currently used to relieve CTLA-4-mediated inhibition of anti-tumor immune response in metastatic...

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Detalles Bibliográficos
Autores principales:	Laurent, Stefania, Queirolo, Paola, Boero, Silvia, Salvi, Sandra, Piccioli, Patrizia, Boccardo, Simona, Minghelli, Simona, Morabito, Anna, Fontana, Vincenzo, Pietra, Gabriella, Carrega, Paolo, Ferrari, Nicoletta, Tosetti, Francesca, Chang, Lung-Ji, Mingari, Maria Cristina, Ferlazzo, Guido, Poggi, Alessandro, Pistillo, Maria Pia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663700/ https://www.ncbi.nlm.nih.gov/pubmed/23634660 http://dx.doi.org/10.1186/1479-5876-11-108

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