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TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR

BACKGROUND: Enhanced EGF receptor (EGFR) signaling is a hallmark of many human cancers, though the role of enhanced EGFR signaling within the surrounding tumor stroma has not been well studied. The myofibroblast is an important stromal cell that demonstrates enhanced EGFR expression in the setting o...

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Detalles Bibliográficos
Autores principales:	Yoo, James, Rodriguez Perez, Citlali Ekaterina, Nie, Wenxian, Sinnett-Smith, James, Rozengurt, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663734/ https://www.ncbi.nlm.nih.gov/pubmed/23688423 http://dx.doi.org/10.1186/1471-230X-13-90

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