Notch1 signaling is involved in regulating Foxp3 expression in T-ALL

BACKGROUND: T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. Immune tolerance induced by CD4(+)CD25(+) regulatory T cells (Tregs) with high expression of Foxp3 is an important hypothesis for poor therapy response. Notch1 signaling is thought to be involved i...

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Detalles Bibliográficos
Autores principales: Luo, Xiaodan, Tan, Huo, Zhou, Yueqiao, Xiao, Tiantian, Wang, Chunyan, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663738/
https://www.ncbi.nlm.nih.gov/pubmed/23578365
http://dx.doi.org/10.1186/1475-2867-13-34

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